1-Methoxy-3-trimethylsiloxy-1,3-butadiene, 96%, Thermo Scientific Chemicals

Product Code	Brand	Quantity
11323646	Thermo Scientific Alfa Aesar L14672.03	1 g
11333646	Thermo Scientific Alfa Aesar L14672.06	5 g

Description

1-Methoxy-3-trimethylsiloxy-1,3-butadiene is employed as a reagent in Mannich-Michael reaction for the synthesis of piperidinones and enaminones. As Diels-Alder diene, it is used in the synthesis of pyridones and pyranones, sulfone analogues of griseofulvin (sulfogriseofulvins) and 4H-1-aminopyrroles and 4, 5H-pyrazoles.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
1-Methoxy-3-trimethylsiloxy-1,3-butadiene is employed as a reagent in Mannich-Michael reaction for the synthesis of piperidinones and enaminones. As Diels-Alder diene, it is used in the synthesis of pyridones and pyranones, sulfone analogues of griseofulvin (sulfogriseofulvins) and 4H-1-aminopyrroles and 4, 5H-pyrazoles.

Solubility
Miscible with most organic solvents. Immiscible with water.

Notes
Moisture sensitive. Store in cool place. Incompatible with strong oxidizing agents and strong acids.

Chemical Identifiers

• CAS: 54125-02-9
• Molecular Weight (g/mol): 172.299
• InChI Key: SHALBPKEGDBVKK-VOTSOKGWSA-N
• PubChem CID: 5366448
• SMILES: COC=CC(=C)O[Si](C)(C)C

• Molecular Formula: C8H16O2Si
• MDL Number: MFCD00008498
• Synonym: danishefsky's diene, 1-methoxy-3-trimethylsiloxy-1,3-butadiene, unii-1zor63u51o, 1-methoxy-3-trimethylsiloxy butadiene, 1-methoxy-3-trimethylsilyloxy-1,3-butadiene, e-4-methoxybuta-1,3-dien-2-yl oxy trimethylsilane, e-4-methoxybuta-1,3-dien-2-yloxy trimethylsilane, 1-methoxy-3-trimethylsilyloxy butadiene, silane, 2e-3-methoxy-1-methylene-2-propenyl oxy trimethyl, e-1-methoxy-3-trimethylsilyloxy-1,3-butadiene
• IUPAC Name: [(3E)-4-methoxybuta-1,3-dien-2-yl]oxy-trimethylsilane

Specifications

• Boiling Point: 68°C to 69°C (14mmHg)
• Molecular Formula: C8H16O2Si
• UN Number: UN1993
• Flash Point: 45°C (113°F)
• Synonym: danishefsky's diene, 1-methoxy-3-trimethylsiloxy-1,3-butadiene, unii-1zor63u51o, 1-methoxy-3-trimethylsiloxy butadiene, 1-methoxy-3-trimethylsilyloxy-1,3-butadiene, e-4-methoxybuta-1,3-dien-2-yl oxy trimethylsilane, e-4-methoxybuta-1,3-dien-2-yloxy trimethylsilane, 1-methoxy-3-trimethylsilyloxy butadiene, silane, 2e-3-methoxy-1-methylene-2-propenyl oxy trimethyl, e-1-methoxy-3-trimethylsilyloxy-1,3-butadiene
• InChI Key: SHALBPKEGDBVKK-VOTSOKGWSA-N
• IUPAC Name: [(3E)-4-methoxybuta-1,3-dien-2-yl]oxy-trimethylsilane
• PubChem CID: 5366448
• Percent Purity: 97%
• Sensitivity: Air and moisture sensitive
• Chemical Name or Material: 1-Methoxy-3-trimethylsiloxy-1,3-butadiene

• CAS: 54125-02-9
• MDL Number: MFCD00008498
• Beilstein: 1616761
• Merck Index: 14,6001
• Solubility Information: Miscible with most organic solvents. Immiscible with water.
• SMILES: COC=CC(=C)O[Si](C)(C)C
• Molecular Weight (g/mol): 172.299
• Formula Weight: 172.3
• Refractive Index: 1.455
• Density: 0.89

Safety and Handling

GHS H Statement
H226
Flammable liquid and vapor.

P210-P233-P240-P241-P242-P243-P280-P303+P361+P353-P370+P378q-P501c

H226

missing translation for 'dotInformation' : Transport Hazard Class: 3; Packing Group: III; Proper Shipping Name: FLAMMABLE LIQUIDS, N.O.S.

missing translation for 'tsca' : No

Recommended Storage : Keep cold; Store under Argon

RUO – Research Use Only