Ketoconazole, Fisher BioReagents

Product Code	Brand	Quantity	Packaging
10430015	Fisher BioReagents BP2734-50	50 mg	Amber Glass
10754344	Fisher BioReagents BP2734-100	100 mg	Amber Glass
10032624	Fisher BioReagents BP2734-500	500 mg	Amber Glass
11448353	Fisher BioReagents BP2734-1	1 g	Amber Glass

Description

Ketoconazole is a cytochrome P450 inhibitor and demonstrates anti-psoriatic activity. An antifungal agent.

Chemical Identifiers

• CAS: 65277-42-1
• Molecular Weight (g/mol): 534.452
• Synonym: ketoconazole
• IUPAC Name: 2,2,2-trideuterio-1-[4-[4-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]ethanone

• Molecular Formula: C26H28Cl2N4O4
• InChI Key: XMAYWYJOQHXEEK-SIULDFEJSA-N
• PubChem CID: 76973198
• SMILES: CC(=O)N1CCN(CC1)C2=CC=C(C=C2)OCC3COC(O3)(CN4C=CN=C4)C5=C(C=C(C=C5)Cl)Cl

Specifications

• CAS: 65277-42-1
• Color: White
• Loss on Drying: < 0.5%
• Assay Percent Range: 98%
• Merck Index: 15, 5349
• InChI Key: XMAYWYJOQHXEEK-SIULDFEJSA-N
• IUPAC Name: 2,2,2-trideuterio-1-[4-[4-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]ethanone
• PubChem CID: 76973198
• Physical Form: Solid

• Melting Point: 148°C
• Ignition Residue: < 0.1%
• Melting Range: Inclusive between 148°C
• Molecular Formula: C26H28Cl2N4O4
• Synonym: ketoconazole
• SMILES: CC(=O)N1CCN(CC1)C2=CC=C(C=C2)OCC3COC(O3)(CN4C=CN=C4)C5=C(C=C(C=C5)Cl)Cl
• Molecular Weight (g/mol): 534.452
• Formula Weight: 531.44
• Chemical Name or Material: Ketoconazole

Safety and Handling

WARNING!

Emergency Overview
Toxic if swallowed. May cause skin, eye, and respiratory tract irritation. Danger of serious damage to health by prolonged exposure. Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. Use personal protective equipment. Use only under a chemical fume hood. Wash off immediately with plenty of water for at least 15 minutes. Immediate medical attention is required. Rinse immediately with plenty of water, also under the eyelids, for at least 15 minutes. Immediate medical attention is required. Move to fresh air. If breathing is difficult, give oxygen. If breathing is difficult, give oxygen. Do not use mouth-to-mouth resuscitation if victim ingested or inhaled the substance; induce artifici.

NFPA

Health:3
Flammability:0
Instability:0

missing translation for 'dotInformation' : DOT Class 6.1, : Poison

Recommended Storage : RT

Product Identifier

• Ketoconazole

Signal Word

• Danger

Hazard Category

• Acute toxicity Category 3
• LONG-TERM AQUATIC HAZARD Chronic 1
• ACUTE AQUATIC Acute 1
• Reproductive toxicity Category 1B
• Specific target organ toxicity after repeated exposure Category 2

Hazard Statement

• H400-Very toxic to aquatic life.
• H410-Very toxic to aquatic life with long lasting effects.
• H360F-May damage fertility.
• H373-May cause damage to organs.
• H301-Toxic if swallowed.

Precautionary Statement

• P201-Obtain special instructions before use.
• P264-Wash thoroughly after handling.
• P270-Do not eat, drink or smoke when using this product.
• P273-Avoid release to the environment.
• P280-Wear protective gloves/protective clothing/eye protection/face protection.
• P308+P313-IF exposed or concerned: Get medical advice/attention.