1-Methyl-1H-pyrazole-4-boronic acid pinacol ester, 97%, Thermo Scientific Chemicals

Product Code	Brand	Quantity
15460416	Thermo Scientific Alfa Aesar H53139.MD	250 mg
15450416	Thermo Scientific Alfa Aesar H53139.03	1 g

Description

It is a reagent used for Suzuki-Miyaura cross-coupling reactions, transesterification reactions. It is involved in several reactions as a reagent for the preparation of aminothiazoles as γ-secretase modulators,amino-pyrido-indol-carboxamides, as potential JAK2 inhibitors for myeloproliferative disorders therapy, pyridine derivatives as TGF-β1 and active A signaling inhibitors and MK-2461 analogs as inhibitors of c-Met kinase for the treatment of cancer.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
It is a reagent used for Suzuki-Miyaura cross-coupling reactions, transesterification reactions. It is involved in several reactions as a reagent for the preparation of aminothiazoles as γ-secretase modulators,amino-pyrido-indol-carboxamides, as potential JAK2 inhibitors for myeloproliferative disorders therapy, pyridine derivatives as TGF-β1 and active A signaling inhibitors and MK-2461 analogs as inhibitors of c-Met kinase for the treatment of cancer.

Solubility
Slightly soluble in water.

Notes
Store in cool dry place. Ensure proper ventilation. Incompatible with oxidizing agents.

Chemical Identifiers

• CAS: 761446-44-0
• Molecular Weight (g/mol): 208.07
• InChI Key: UCNGGGYMLHAMJG-UHFFFAOYSA-N
• PubChem CID: 2773987
• SMILES: CN1C=C(C=N1)B1OC(C)(C)C(C)(C)O1

• Molecular Formula: C10H17BN2O2
• MDL Number: MFCD03789259
• Synonym: 1-methyl-4-4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl-1h-pyrazole, 1-methylpyrazole-4-boronic acid pinacol ester, 1-methyl-4-4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl pyrazole, 1-methyl-1h-pyrazole-4-boronic acid pinacol ester, 1-methyl-4-tetramethyl-1,3,2-dioxaborolan-2-yl-1h-pyrazole, 1-methyl-pyrazole-4-boronic acid pinacol ester, 1-methyl-4-4,4,5,5-tetramethyl-1,3,2 dioxaborolan-2-yl-1h-pyrazole, 1h-pyrazole, 1-methyl-4-4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl, 1-methyl-4-tetramethyl-1,3,2-dioxaborolan-2-yl pyrazole, 1-methyl-4-pyrazoleboronic acid pinacol ester
• IUPAC Name: 1-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole

Specifications

• CAS: 761446-44-0
• Molecular Formula: C10H17BN2O2
• Synonym: 1-methyl-4-4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl-1h-pyrazole, 1-methylpyrazole-4-boronic acid pinacol ester, 1-methyl-4-4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl pyrazole, 1-methyl-1h-pyrazole-4-boronic acid pinacol ester, 1-methyl-4-tetramethyl-1,3,2-dioxaborolan-2-yl-1h-pyrazole, 1-methyl-pyrazole-4-boronic acid pinacol ester, 1-methyl-4-4,4,5,5-tetramethyl-1,3,2 dioxaborolan-2-yl-1h-pyrazole, 1h-pyrazole, 1-methyl-4-4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl, 1-methyl-4-tetramethyl-1,3,2-dioxaborolan-2-yl pyrazole, 1-methyl-4-pyrazoleboronic acid pinacol ester
• InChI Key: UCNGGGYMLHAMJG-UHFFFAOYSA-N
• IUPAC Name: 1-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole
• PubChem CID: 2773987
• Percent Purity: 97%

• Melting Point: 59°C to 64°C
• MDL Number: MFCD03789259
• Solubility Information: Slightly soluble in water.
• SMILES: CN1C=C(C=N1)B1OC(C)(C)C(C)(C)O1
• Molecular Weight (g/mol): 208.07
• Formula Weight: 208.07
• Chemical Name or Material: 1-Methyl-1H-pyrazole-4-boronic acid pinacol ester

Safety and Handling

GHS H Statement
H301-H315-H319-H335
Toxic if swallowed.
Causes skin irritation.
Causes serious eye irritation.
May cause respiratory irritation.

P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P362-P501c

H315-H319-H335

missing translation for 'tsca' : No

Recommended Storage : Ambient temperatures

RUO – Research Use Only