VTCN1 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Brand:  Proteintech 12080-1-AP-20UL

Product Code. 16839583

Description

B7-H4 (B7x, VTCN1) a costimulatory protein which is reported to function as a negative regulator of T-cell mediated immunity. Although B7-H4 binds an unknown receptor, it is thought to deliver an inhibitory signal to T-cells preventing their proliferation, cell cycle progression and interleukin-2 production. B7-H4 deficient mice are only minimally affected; suggesting B7-H4 is important in the fine tuning of the T-cell mediated immune response. B7-H4 is expressed on activated T-cells, B-cells, monocytes and dendritic cells. Aberrant expression has been associated with cancers of the lung, breast and ovary in humans. B7-H4 is expressed primarily on the membrane of lymphoid cells, and as an immunoinhibitory protein that interacts with receptors on the surface of T lymphocytes, it is involved in mediating cellular and humoral immune responses. Overexpression of B7-H4 is associated with certain maligcies, including ovarian and breast cancer, which may be a mechanism by which tumor cells suppress T cell immunity and facilitate tumor progression. Further, VTCN1 may be a useful biomarker for the early detection of ovarian cancer and Renal Cell Carcinoma (RCC).

Specifications

• Antigen: VTCN1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: VTCN1
• Gene Alias: B7 H4, B7h.5, B7H4, B7S1, B7X, PRO1291, Protein B7S1, RP11 229A19.4, VCTN1, VTCN1
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 242122, 295322, 79679
• Content And Storage: -20°C
• Form: Liquid

• Applications: Western Blot, Immunohistochemistry (Paraffin)
• Concentration: 0.23 mg/mL
• Formulation: PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
• Gene Accession No.: Q501W4, Q7TSP5, Q7Z7D3
• Gene Symbols: VTCN1
• Immunogen: VTCN1 Fusion Protein Ag2712
• Quantity: 20 μL
• Primary or Secondary: Primary
• Target Species: Rat, Mouse, Human
• Product Type: Antibody
• Isotype: IgG