Thermo Scientific Chemicals U0126, ≥99%

Product Code	Brand	Quantity
15423859	Thermo Scientific Chemicals J61246.MC	100 mg
15413859	Thermo Scientific Chemicals J61246.MB	25 mg
15403859	Thermo Scientific Chemicals J61246.|H	300 mg

Description

U0126, is used as a selective MAP Kinase Kinase (MKK, MEK) inhibitor. U-0126 has been observed to inhibit promoters containing an AP-1 response element, while in contrast having no effect on promoters that lack an AP-1 response group. U-0126 is also useful in neuronal studies in mice since it displays inhibitory effects against oxidative stress. U-0126 is an activator of PGC-1, mtTFA and nuclear respiratory factor.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Chemical Identifiers

• CAS: 109511-58-2
• Molecular Formula: C₁₈H₁₆N₆S₂, C18H16N6S2
• Synonym: 1,4-Diamino-2,3-dicyano-1,4-bis(2-aminophenylthio)butadiene

Specifications

• Description: White
• For Use With (Application): Selective inhibitor of mitogen-activated protein kinases MEK-1 and MEK-2
• Molecular Formula: C₁₈H₁₆N₆S₂, C18H16N6S2
• Synonym: 1,4-Diamino-2,3-dicyano-1,4-bis(2-aminophenylthio)butadiene
• Product Type: Signal Transduction Reagent
• InChI Key: DVEXZJFMOKTQEZ-JYFOCSDGSA-N
• IUPAC Name: (2Z,3Z)-bis({amino[(2-aminophenyl)sulfanyl]methylidene})butanedinitrile
• Assay: ≥99%

• Content And Storage: -30°C to -10°C
• CAS: 109511-58-2
• Formula Weight: 380.49g/mol
• Solubility: Soluble in DMSO; Poorly soluble in ethanol and water
• Form: Powder
• SMILES: N\C(SC1=CC=CC=C1N)=C(\C#N)/C(/C#N)=C(\N)SC1=CC=CC=C1N
• Molecular Weight (g/mol): 380.49

Safety and Handling

Recommended Storage : Store at -20°C

RUO – Research Use Only