TCR gamma/delta Monoclonal Antibody (UC7-13D5), Alexa Fluor™ 488, Invitrogen™

Armenian Hamster Monoclonal Antibody

Brand:  Invitrogen A15407

Product Code. 15225724

Description

TCR gamma/delta (T-cell receptor gamma/delta) are specialized T-cells in the immune system. The ability of T cell receptors (TCR) to discriminate foreign from self-peptides presented by major histocompatibility complex (MHC) class II molecules is essential for an effective adaptive immune response. TCR recognition of self-peptides has been linked to autoimmune disease. Mutant self-peptides have been associated with tumors. Engagement of TCRs by a family of bacterial toxins know as superantigens has been responsible for toxic shock syndrome. Autoantibodies to V beta segments of T cell receptors have been isolated from patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). The autoantibodies block TH1-mediated inflammatory auto-destructive reactions and are believed to be a method by which the immune system compensates for disease. Most human T cells express the TCR alpha-beta and either CD4 or CD8 molecule (single positive, SP). However, a small number of T cells lack both CD4 and CD8 (double negative, DN). Increased percentages of alpha-beta DN T cells have been identified in some autoimmune and immunodeficiency disorders. Gamma-delta T cells are primarily found within the epithelium. They show less TCR diversity and recognize antigens differently than alpha-beta T cells. Subsets of gamma-delta T cells have shown antitumor and immunoregulatory activity.

Specifications

• Antigen: TCR gamma/delta
• Classification: Monoclonal
• Concentration: 0.5 mg/mL
• Formulation: PBS with <0.1% sodium azide
• Gene Accession No.: 0
• Gene Symbols: Tcrd, Tcrg
• Immunogen: This Armenian hamster IgG is specific to the -gamma -delta T-cell receptor (TCR) complex.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Mouse
• Product Type: Antibody
• Isotype: IgG3

• Applications: Flow Cytometry
• Clone: UC7-13D5
• Conjugate: Alexa Fluor 488
• Gene: Tcrd
• Gene Alias: RGD1311300; similar to T cell receptor V delta 6; T cell receptor gamma locus; T3/TCR complex; TCR delta gamma; TCR gamma/delta; TCR-CD3 complex; Tcrg; Trg; Trg@
• Host Species: Armenian Hamster
• Purification Method: purified
• Regulatory Status: RUO
• Gene ID (Entrez): 110066, 110067
• Content And Storage: 4° C, store in dark
• Form: Liquid