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TBC1D23 Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Brand: Thermo Scientific PA558274
Additional Details : Weight : 0.02000kg
Description
Immunogen sequence: HLSTAFHLDS DLMLQNPSEF AQSVKSLLEA QKQSIESGSI AGGEHLCFMG SGREEEDMYM NMVLAHFLQK NKEYVSIASG GFMALQQHLA DINVDGPENG Y Highest antigen sequence identity to the following orthologs: Mouse - 97%, Rat - 96%.
Putative Rab GTPase-activating protein which plays a role in vesicular trafficking (PubMed:28823707). Involved in endosome-to-Golgi trafficking. Acts as a bridging protein by binding simultaneously to golgins, including GOLGA1 and GOLGA4, located at the trans-Golgi, and to the WASH complex, located on endosome-derived vesicles (PubMed:29084197, PubMed:29426865). Together with WDR11 complex facilitates the golgin-mediated capture of vesicles generated using AP-1 (PubMed:29426865). Plays a role in brain development, including in cortical neuron positioning. May also be important for neurite outgrowth, possibly through its involvement in membrane trafficking and cargo delivery, 2 processes that are essential for axonal and dendritic growth. May act as a general inhibitor of innate immunity signaling, strongly inhibiting multiple TLR and dectin/CLEC7A-signaling pathways. Does not alter initial activation events, but instead affects maintenance of inflammatory gene expression several hours after bacterial lipopolysaccharide (LPS) challenge. [UniProt]Specifications
TBC1D23 | |
Polyclonal | |
Unconjugated | |
TBC1D23 | |
4930451A13Rik; AU015720; AU043671; AU043778; D030022P07Rik; HCV non-structural protein 4A-transactivated protein 1; HCV nonstructural protein 4A-transactivated protein 1; hypothetical protein LOC393459; NS4ATP1; RGD1307925; TBC1 domain family member 23; TBC1 domain family, member 23; TBC1D23; W51689; zgc:63756 | |
Rabbit | |
Antigen affinity chromatography | |
RUO | |
55773 | |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
Liquid |
Immunocytochemistry, Immunohistochemistry (Paraffin) | |
0.1 mg/mL | |
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2 | |
Q9NUY8 | |
TBC1D23 | |
Recombinant protein corresponding to Human TBC1D23 | |
100 μL | |
Primary | |
Human | |
Antibody | |
IgG |
Research Use Only