SPACA1 Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Brand:  Thermo Scientific PA555400

Product Code. 15743321

Description

Immunogen sequence: REVILTNGCP GGESKCVVRV EECRGPTDCG WGKPISESLE SVRLACIHTS PLNRFKYMWK L Highest antigen sequence identity to the following orthologs: Mouse - 85%, Rat - 89%.

The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein expressed by this gene is recognized by anti-sperm antibodies from infertile males. Furthermore, antibodies generated against the recombinant protein block in vitro fertilization. This protein localizes to the acrosomal membrane of spermatids and mature spermatozoa where it is thought to play a role in acrosomal morphogenesis and in sperm-egg binding and fusion, respectively.

Specifications

• Antigen: SPACA1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SPACA1
• Gene Alias: 1700124L11Rik; 4930540L03Rik; RGD1560284; SAMP32; SPACA1; Sperm acrosomal membrane-associated protein 32; sperm acrosome associated 1; sperm acrosome membrane-associated protein 1
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 81833
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry, Western Blot
• Concentration: 0.1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q9HBV2
• Gene Symbols: SPACA1
• Immunogen: Recombinant protein corresponding to Human SPACA1
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Research Use Only