Phospho-HNF4A (Ser313) Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Brand:  Invitrogen PA539695

Product Code. 15576561

Description

Hepatocyte nuclear factor 4 alpha (HNF4 alpha) is a transcription factor that belongs to the steroid hormone receptor superfamily and is enriched in liver. HNF4 alpha, in association with PGC-1 alpha, activates gluconeogenic genes such as phosphoenolpyruvate carboxykinase and glucose-6-phosphatase genes in fasted livers. Conditional knockout of the HNF4 alpha gene in the mouse liver destroys lipid homeostasis and leads to lipid accumulation in the liver and a reduction of serum cholesterol and triglyceride levels. Mutations in HNF4 alpha have been linked to maturity-onset diabetes of the young (MODY).

Specifications

• Antigen: Phospho-HNF4A (Ser313)
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: HNF4A
• Gene Alias: Hepatocyte nuclear factor 4-alpha, HNF-4-alpha, Nuclear receptor subfamily 2 group A member 1, Transcription factor 14, TCF-14, Transcription factor HNF-4, HNF4A, HNF4, NR2A1, TCF14
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 15378, 25735, 3172
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: Dulbecco′s PBS with 150mM NaCl, 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: P41235, P49698, P22449
• Gene Symbols: HNF4A
• Immunogen: A synthetic phosphopeptide derived from human HNF4alpha around the phosphorylation site of Ser313 (L-R-SP-Q-V)
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG