p65/RELA Rabbit anti-Human, Mouse, Porcine, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Brand:  Proteintech 10745-1-AP-20UL

Product Code. 16817333

Description

This antibody is a rabbit polyclonal antibody raised against residues near the N terminus of human RELA.

The transcription factor NFkB is widely recognized as a critical mediator of immune and inflammatory responses. In most cell types, NFkB is found in the cytoplasm where it is associated with an inhibitory protein known as IkB. An impressive variety of stimuli (tumor necrosis factor, interleukin 1, T-cell activation signals, bacterial endotoxins, viral transforming proteins, certain growth factors and reactive oxygen intermediates) lead to the rapid nuclear assumulation of NFkB by the induced phosphorylation and subsquent degradation of IkB. In the nucleus, NFkB regulates genes encoding cytokines, cytokine receptors, cell adhesion molecules, proteins involved in coagulation and genes involved in cell growth control. Additionally, NFkB is thought to be an important transcriptional regulator for HIV. Growing evidence indicates that the dysregulation of NFkB may be key to a number of diseases including arthritis and other inflammatory diseases, Alzheimer′s disease, atherosclerosis, and cancer.

Specifications

• Antigen: p65/RELA
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: RELA
• Gene Alias: NFKB 3, NFKB p65, NFKB3, p65, RELA, Transcription factor p65
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 100135665, 19697, 309165, 5970
• Content And Storage: -20°C
• Form: Liquid

• Applications: Flow Cytometry, Immunoprecipitation, Immunofluorescence, Immunohistochemistry (Paraffin), Immunocytochemistry
• Concentration: 0.52 mg/mL
• Formulation: PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
• Gene Accession No.: Q04206, Q04207
• Gene Symbols: RELA
• Immunogen: p65; RELA Fusion Protein Ag1199
• Quantity: 20 μL
• Primary or Secondary: Primary
• Target Species: Human, Porcine, Rat, Mouse
• Product Type: Antibody
• Isotype: IgG