Macherey-Nagel™ MSTFA Silylation Reagent

Complete silylation reactions with high reaction rates, even without a catalyst. MSTFA Silylation Reagent is the most volatile trimethylsilyl amide available.

Product Code	Brand	Quantity
10319827	Macherey-Nagel™ 701270.1100	100 mL
10535631	Macherey-Nagel™ 701270.110	10 mL

Description

• N-methyl-N-trimethylsilyl-trifluoroacetamide
• M 199.1g/mol, Bp 70°C (75 mm Hg), density d20°/4° = 1.11
• MSTFA: R' = CF3, R" = CH3
• The most volatile trimethylsilyl amide available
• Very strong TMS donor which does not cause any noticeable FID fouling even after long-time measuring series
• The already good solution characteristics can be improved by addition of submolar quantities of protic solvents (e.g., TFA for extremely polar compounds such as hydrochlorides) or pyridine (e.g., for carbohydrates).
• Recommended application: carboxylic acids, hydroxy and ketocarboxylic acids, amino acids, amines, alcohols, polyalcohols, sugars, mercaptans and similar compounds with active hydrogen atoms. Even amine hydrochlorides can be silylated directly.
• Advantages: complete reaction with high reaction rates, even without a catalyst (1–2 % TMCS or TSIM)
• The by-product of the reaction (N-methyltrifluoroacetamide) features high volatility and short retention time.