Histamine dihydrochloride, 98+%, Thermo Scientific Chemicals

Product Code	Brand	Quantity
11387276	Thermo Scientific Alfa Aesar L09198.06	5 g
11397276	Thermo Scientific Alfa Aesar L09198.14	25 g

Description

Histamine dihydrochloride has been shown to activate nitric oxide synthetase and suppress or inhibit the generation of reactive oxygen species (ROS). Inhibition of ROS by histamine dihydrochloride allows activation of T cells and NK cells by IL-2. In a rat model, histamine dihydrochloride suppressed ROS generated by Kupffer cells through the H2 histamine receptor. It is a potent vasodilator and endogenous histamine receptor agonist.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Histamine dihydrochloride has been shown to activate nitric oxide synthetase and suppress or inhibit the generation of reactive oxygen species (ROS). Inhibition of ROS by histamine dihydrochloride allows activation of T cells and NK cells by IL-2. In a rat model, histamine dihydrochloride suppressed ROS generated by Kupffer cells through the H2 histamine receptor. It is a potent vasodilator and endogenous histamine receptor agonist.

Solubility
Very soluble in water and methanol. Soluble in ethanol.

Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Incompatible with strong oxidizing agents. Store away from oxidizing agents. Store at 4°C.

Chemical Identifiers

• CAS: 56-92-8
• Molecular Weight (g/mol): 184.06
• InChI Key: PPZMYIBUHIPZOS-UHFFFAOYSA-N
• PubChem CID: 5818
• SMILES: [H+].[H+].[Cl-].[Cl-].NCCC1=CN=CN1

• Molecular Formula: C5H11Cl2N3
• MDL Number: MFCD00012703
• Synonym: histamine dihydrochloride, histamine 2hcl, 2-1h-imidazol-4-yl ethanamine dihydrochloride, 1h-imidazole-4-ethanamine dihydrochloride, 1h-imidazole-4-ethanamine, dihydrochloride, peremin, ceplene, 2-1h-imidazol-4-yl ethylamine dihydrochloride, 2-4-imidazolyl ethylamine dihydrochloride, histaminedium dichloride
• IUPAC Name: 2-(1H-imidazol-5-yl)ethanamine;dihydrochloride

Specifications

• CAS: 56-92-8
• Molecular Formula: C5H11Cl2N3
• Beilstein: 3624116
• Synonym: histamine dihydrochloride, histamine 2hcl, 2-1h-imidazol-4-yl ethanamine dihydrochloride, 1h-imidazole-4-ethanamine dihydrochloride, 1h-imidazole-4-ethanamine, dihydrochloride, peremin, ceplene, 2-1h-imidazol-4-yl ethylamine dihydrochloride, 2-4-imidazolyl ethylamine dihydrochloride, histaminedium dichloride
• InChI Key: PPZMYIBUHIPZOS-UHFFFAOYSA-N
• IUPAC Name: 2-(1H-imidazol-5-yl)ethanamine;dihydrochloride
• PubChem CID: 5818
• Percent Purity: ≥98%

• Melting Point: 245°C to 249°C
• MDL Number: MFCD00012703
• Merck Index: 14,4719
• Solubility Information: Very soluble in water and methanol. Soluble in ethanol.
• SMILES: [H+].[H+].[Cl-].[Cl-].NCCC1=CN=CN1
• Molecular Weight (g/mol): 184.06
• Formula Weight: 184.07
• Chemical Name or Material: Histamine dihydrochloride

Safety and Handling

GHS H Statement
H334-H335-H315-H319-H317
May cause allergy or asthma symptoms or breathing difficulties if inhaled.
May cause respiratory irritation.
Causes skin irritation.
Causes serious eye irritation.
May cause an allergic skin reaction.

P261-P264b-P271-P272-P280-P285-P302+P352-P304+P340-P305+P351+P338-P333+P313-P342+P311-P362-P501c

H315-H317-H319-H334-H335

missing translation for 'einecsNumber' : 200-298-4

missing translation for 'rtecsNumber' : MS1575000

missing translation for 'tsca' : Yes

Recommended Storage : Ambient temperatures

RUO – Research Use Only