HDAC4 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Product Code	Brand	Quantity
16897334	Proteintech 17449-1-AP-20UL	20 μL
16887334	Proteintech 17449-1-AP-150UL	150 μL

Description

This antibody is a rabbit polyclonal antibody raised against an internal region of human HDAC4. The calculated molecular weight of HDAC4 is 106 kDa, but modified HDAC4 is about 140 kDa.

Histone deacetylase 4 (HDAC4) is responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3, and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. HDAC4 is also involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D. It is also involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. Mutations to the HDAC4 gene have been found in Brachydactyly-mental retardation syndrome (BDMR).

Specifications

• Antigen: HDAC4
• Applications: Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
• Conjugate: Unconjugated
• Host Species: Rabbit
• Target Species: Human, Mouse, Rat
• Gene Accession No.: P56524, Q6NZM9, Q99P99
• Gene ID (Entrez): 208727, 363287, 9759
• Immunogen: HDAC4 Fusion Protein Ag11572
• Primary or Secondary: Primary
• Content And Storage: -20°C
• Gene: HDAC4

• Concentration: 0.21 mg/mL
• Classification: Polyclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Alias: HA6116, HD4, HDAC A, HDAC4, HDACA, histone deacetylase 4, KIAA0288
• Gene Symbols: Hdac4
• Isotype: IgG
• Purification Method: Antigen Affinity Chromatography
• Product Type: Antibody