Guanidine Hydrochloride, Ultra Pure grade, MP Biomedicals

Product Code	Brand	Quantity
11441682	MP Biomedicals 04820512	100 g
11461682	MP Biomedicals 04820540	1 kg

Description

• Guanidine Hydrochloride is a strong chaotropic agent useful for the denaturation and subsequent refolding of proteins
• This strong denaturant can solubilize insoluble or denatured proteins such as inclusion bodies
• This can be used as the first step in refolding proteins or enzymes into their active form
• Urea and dithiothreitol (DTT) may also be necessary
• Guanidine HCl is used in the isolation of RNA to dissociate the nucleoprotein into its nucleic acid and protein moieties
• It is an inhibitor of RNase
• Highly concentrated (6 - 8 M) Guanidine HCl solutions are used to denature native globular proteins
• It apparently disrupts hydrogen bonds which hold the protein in its unique structure; however, there also is evidence suggesting that guanidine hydrocholoride may disrupt hydrophobic interactions by promoting the solubility of hydrophobic residues in aqueous solutions

Chemical Identifiers

• CAS: 50-01-1
• Molecular Weight (g/mol): 95.53
• InChI Key: PJJJBBJSCAKJQF-UHFFFAOYSA-N
• PubChem CID: 5742
• IUPAC Name: guanidine;hydrochloride

• Molecular Formula: CH6ClN3
• MDL Number: MFCD00013026
• Synonym: guanidine hydrochloride, guanidinium chloride, guanidine, monohydrochloride, aminoformamidine hydrochloride, aminomethanamidine hydrochloride, guanidine monohydrochloride, guanidine hcl, guanidine chloride, iminourea hydrochloride, carbamidine hydrochloride
• ChEBI: CHEBI:32735
• SMILES: C(=N)(N)N.Cl

Specifications

• CAS: 50-01-1
• Color: White
• Linear Formula: CH5N3·HCl
• Synonym: guanidine hydrochloride, guanidinium chloride, guanidine, monohydrochloride, aminoformamidine hydrochloride, aminomethanamidine hydrochloride, guanidine monohydrochloride, guanidine hcl, guanidine chloride, iminourea hydrochloride, carbamidine hydrochloride
• InChI Key: PJJJBBJSCAKJQF-UHFFFAOYSA-N
• IUPAC Name: guanidine;hydrochloride
• PubChem CID: 5742
• Formula Weight: 95.53
• Grade: Ultra Pure
• Chemical Name or Material: GUANIDINE HYDROCHLORIDE

• Melting Point: 180°C to 190°C
• Molecular Formula: CH6ClN3
• MDL Number: MFCD00013026
• Solubility Information: Soluble in water (6 M - clear, colorless solution).
• SMILES: C(=N)(N)N.Cl
• Molecular Weight (g/mol): 95.53
• ChEBI: CHEBI:32735
• Percent Purity: ≥99%
• Physical Form: Crystalline Powder

Safety and Handling

Recommended Storage : Store at Room Temperature (15-30°C). Store Desiccated.

Product Identifier

• Guanidine Hydrochloride, ultra pure

Signal Word

• Warning

Hazard Category

• Acute toxicity Category 4
• Serious eye damage/eye irritation Category 2
• Skin corrosion/irritation Category 2

Hazard Statement

• H302-Harmful if swallowed.
• H315-Causes skin irritation.
• H319-Causes serious eye irritation.

Precautionary Statement

• P260-Do not breathe dust/fume/gas/mist/vapours/spray.
• P264-Wash thoroughly after handling.
• P280-Wear protective gloves/protective clothing/eye protection/face protection.
• P301+P310-IF SWALLOWED: Immediately call a POISON CENTER/doctor /
• P303+P361+P353-IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water/ shower.
• P305+P351+P338-IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
• P321-Specific treatment (see on this label).
• P501b-Dispose of contents/container in accordance with local/regional/national/international regulations.

Supplemental information

• MIXTURE LIST-Contains : guanadine hydrochloride