Thermo Scientific Chemicals β-Estradiol, 98%

Product Code	Brand	Quantity	Packaging
11916891	Thermo Scientific Chemicals 436320050	5 g	Glass bottle
11906891	Thermo Scientific Chemicals 436320250	25 g	Glass bottle

Description

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• β-Estradiol is a naturally occurring endogenous hormone in females

• It is an important steroid sex hormone involved in the regulation of several biological functions including gene transcription and protein synthesis

• This hormone is produced by the ovaries and can bind to and activate specific nuclear receptors

Applications

• β-Estradiol acts as an estrogenic hormone receptor agonist and activator of PI 3-kinase

• It shows inhibitory activity against aldehyde oxidase

• β-Estradiol presents mild anabolic and metabolic activities and increases blood coagulability in vivo experiments

• It plays a role in immune and inflammatory processes

• β-Estradiol triggers an increase in hepatic synthesis of some proteins, including sex hormone-binding globulin (SHBG), and thyroid-binding globulin (TBG), and suppresses the formation of follicle-stimulating hormone (FSH)

• This compound has been used for the in vitro maturation of bovine cumulus-oocyte complexes (COCs)

Chemical Identifiers

• CAS: 50-28-2
• Molecular Weight (g/mol): 272.38
• Synonym: estradiol, beta-estradiol, 17beta-estradiol, oestradiol, dihydrofolliculin, estrace, ovocyclin, progynon, dihydrotheelin, dihydroxyestrin
• ChEBI: CHEBI:16469
• SMILES: CC12CCC3C(C1CCC2O)CCC4=C3C=CC(=C4)O

• Molecular Formula: C₁₈H₂₄O₂
• InChI Key: VOXZDWNPVJITMN-ZBRFXRBCSA-N
• PubChem CID: 5757
• IUPAC Name: (8R,9S,13S,14S,17S)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol

Specifications

• CAS: 50-28-2
• CAS Max %: 100.0
• Color: White
• Assay Percent Range: 97.5% min. (HPLC)
• Merck Index: 15,3758
• Synonym: estradiol, beta-estradiol, 17beta-estradiol, oestradiol, dihydrofolliculin, estrace, ovocyclin, progynon, dihydrotheelin, dihydroxyestrin
• InChI Key: VOXZDWNPVJITMN-ZBRFXRBCSA-N
• IUPAC Name: (8R,9S,13S,14S,17S)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol
• PubChem CID: 5757
• Formula Weight: 272.38
• Physical Form: Powder

• CAS Min %: 97.5
• Melting Point: 176.0°C to 180.0°C
• Infrared Spectrum: Authentic
• Molecular Formula: C₁₈H₂₄O₂
• Specific Rotation: +76° to +83° (20°C, 589nm) (c=1, dioxane)
• Solubility Information: Solubility in water: insoluble. Other solubilities: soluble in chloroform, hexane, ethyl acetate
• SMILES: CC12CCC3C(C1CCC2O)CCC4=C3C=CC(=C4)O
• Molecular Weight (g/mol): 272.38
• ChEBI: CHEBI:16469
• Percent Purity: 98%
• Chemical Name or Material: β-Estradiol

Sécurité et traitement

GHS H Statement
May cause cancer.
May cause damage to organs through prolonged or repeated exposure.
Suspected of damaging fertility.
Suspected of damaging the unborn child.
May cause harm to breast-fed children.

GHS P Statement
Obtain special instructions before use.
Do not handle until all safety precautions have been read and understood.
Use personal protective equipment as required.
IF exposed or concerned: Get medical advice/attention.

GHS Signal Word: Danger

missing translation for 'einecsNumber' : 200-023-8

Identifiant produit

• beta-Estradiol

Mention d'avertissement

• Danger

Catégorie de danger

• Carcinogenicity Category 1A
• Reproductive toxicity on or via lactation
• Reproductive toxicity Category 2
• Specific target organ toxicity after repeated exposure Category 2

Mention de danger

• H361fd-Suspected of damaging fertility. Suspected of damaging the unborn child.
• H373-May cause damage to organs.
• H362-May cause harm to breast-fed children.
• H350-May cause cancer.

Conseils de prudence

• P201-Obtain special instructions before use.
• P202-Do not handle until all safety precautions have been read and understood.
• P260-Do not breathe dust/fume/gas/mist/vapours/spray.
• P263-Avoid contact during pregnancy/while nursing.
• P280-Wear protective gloves/protective clothing/eye protection/face protection.
• P308+P313-IF exposed or concerned: Get medical advice/attention.

RUO – Research Use Only