DIO1 Monoclonal Antibody (1E4), Invitrogen™

Mouse Monoclonal Antibody

Brand:  Invitrogen MA524403

Product Code. 15612235

Description

Peptide Sequence: DRVKRNILAM GEKTGMTRNP HFSHDNWIPT FFSTQYFWFV LKVRWQRLED TTELGGLAPN CPVVRLSGQR CNIWEFMQGN RPLVLNFGSC T

The protein encoded by this gene is a thiol-requiring propylthiouracil-sensitive oxidoreductase. It activates thyroid hormone by converting the prohormone thyroxine (T4) by outer ring deiodination (ORD) to bioactive 3,3',5-triiodothyronine (T3). It also degrades both hormones by inner ring deiodination (IRD). Alternative splicing results in multiple transcript variants encoding different isoforms. Some, but not all, isoforms contain a selenocysteine (Sec) residue encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Additional transcript variants have been described but are not supported by experimental evidence.

Specifications

• Antigen: DIO1
• Classification: Monoclonal
• Conjugate: Unconjugated
• Gene: Dio1
• Gene Alias: 5DI; D1; deiodinase, iodothyronine type I; deiodinase, iodothyronine, type I; Dio1; DIOI; hDido1; iodothyronine deiodinase type 1; ITDI1; thyroxine 5'-deiodinase; thyroxine deiodinase; thyroxine deiodinase type I (selenoprotein); thyroxine deiodinase, type I; TXDI1; Type 1 DI; type I iodothyronine deiodinase; Type-I 5'-deiodinase
• Host Species: Mouse
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 1733
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA
• Clone: 1E4
• Formulation: PBS with no preservative; pH 7.4
• Gene Accession No.: P49895
• Gene Symbols: Dio1
• Immunogen: DIO1 (NP_000783.2, 35 a.a. ∽ 125 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2a κ