Thermo Scientific Chemicals Chloroquine diphosphate salt, 98%

Product Code	Brand	Quantity
15368865	Thermo Scientific Chemicals 455240250	25 g
15384998	Thermo Scientific Chemicals 455241000	100 g
15394998	Thermo Scientific Chemicals 455245000	500 g

Description

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Information

• Chloroquine diphosphate salt is a DNA intercalator that shows anti-malarial and anti-inflammatory activities.
• It has been described that this compound interferes with the biosynthesis of nucleic acids, suggesting a cellular mechanism of action

Applications

• Chloroquine diphosphate salt is used as a DNA intercalator to dissociate antigen-antibody complexes without denaturing red blood cell antigens
• This compound shows anti-malarial activity against Plasmodium falciparum, except against chloroquine-resistant strains. It has been used in in vitro antiplasmodial assays. In parasites the mechanism of action remains unclear, but this compound can inhibit the parasitic enzyme heme polymerase that converts the toxic heme into non-toxic hemozoin, resulting in the accumulation of toxic heme within the parasite.
• It shows very high anti-viral activity against NiV but lower activity against other viruses at concentrations lower than 20 μM
• Chloroquine diphosphate salt is used to study the role of endosomal acidification in cellular processes, such as the signaling of intracellular TLRs
• Chloroquine diphosphate salt has been used in autophagy inhibition studies

Chemical Identifiers

• CAS: 50-63-5
• Molecular Weight (g/mol): 515.86
• InChI Key: QKICWELGRMTQCR-UHFFFAOYNA-N
• PubChem CID: 64927
• SMILES: OP(O)(O)=O.OP(O)(O)=O.CCN(CC)CCCC(C)NC1=C2C=CC(Cl)=CC2=NC=C1

• Molecular Formula: C18H32ClN3O8P2
• MDL Number: MFCD00069852
• Synonym: chloroquine diphosphate, chloroquine phosphate, aralen phosphate, chingamin phosphate, chloroquine bis phosphate, chingaminum, alermine, h-stadur, aralen diphosphate, miniquine
• IUPAC Name: 4-N-(7-chloroquinolin-4-yl)-1-N,1-N-diethylpentane-1,4-diamine;phosphoric acid

Specifications

• CAS: 50-63-5
• Loss on Drying: 2% max. (105°C, 16 h)
• Assay Percent Range: 97.5% min. (HPLC)
• MDL Number: MFCD00069852
• Solubility Information: Solubility in water: 50g/L. Other solubilities: insoluble in alcohol, benzene, chloroform, ether
• SMILES: OP(O)(O)=O.OP(O)(O)=O.CCN(CC)CCCC(C)NC1=C2C=CC(Cl)=CC2=NC=C1
• Molecular Weight (g/mol): 515.86
• Formula Weight: 515.86
• Chemical Name or Material: Chloroquine diphosphate salt

• Melting Point: 200.0°C
• Infrared Spectrum: Authentic
• Molecular Formula: C18H32ClN3O8P2
• Synonym: chloroquine diphosphate, chloroquine phosphate, aralen phosphate, chingamin phosphate, chloroquine bis phosphate, chingaminum, alermine, h-stadur, aralen diphosphate, miniquine
• InChI Key: QKICWELGRMTQCR-UHFFFAOYNA-N
• IUPAC Name: 4-N-(7-chloroquinolin-4-yl)-1-N,1-N-diethylpentane-1,4-diamine;phosphoric acid
• PubChem CID: 64927
• Percent Purity: 98%

Safety and Handling

GHS H Statement
Harmful if swallowed.

GHS P Statement
IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.

GHS Signal Word: Warning

missing translation for 'einecsNumber' : 200-055-2

Product Identifier

• Chloroquine diphosphate salt

Signal Word

• Warning

Hazard Category

• Acute toxicity Category 4

Hazard Statement

• H302-Harmful if swallowed.

Precautionary Statement

• P264-Wash thoroughly after handling.
• P301+P312-IF SWALLOWED: Call a POISON CENTER or doctor/physician/ if you feel unwell.

RUO – Research Use Only