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IBA Lifesciences CD3/CD28 Streptamer™ Kit
T cell activation and expansion with removable stimulation reagents
Brand: IBA Lifesciences 6-8900-050
This item is not returnable.
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Description
- The CD3/CD28 Streptamer™ approach is based on our Strep-tag™ technology and facilitates T cell activation and expansion
- Low affinity, Fab fragments fused to a Twin-Strep-tag™ (Fab-Streps) against CD3 and CD28 are multimerized on a Strep-Tactin™ backbone
- The resulting CD3/CD28 Streptamer™ complex stimulates the T cell receptor/CD3 complex (TCR/CD3; signal 1) and the co-stimulatory molecule CD28 (signal 2)
- Providing these two signals leads to efficient T cell activation and proliferation
- For in vitro stimulation and activation, the soluble CD3/CD28 Streptamers are added to T cells
- The addition of biotin reverses the multimerization and causes the dissociation of low affinity Fab fragments from the cells
- Consequently, the termination of stimulation is possible at any point in time
Specifications
| Human | |
| For T Cell Activation and Expansion |
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