Beta Catenin Rabbit anti-Human, CoraLite 555, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Brand:  Proteintech CL555-51067-100UL

Product Code. 17224766

Description

β-Catenin, also known as CTNNB1, is an evolutionarily conserved, multifunctional intracellular protein. β-Catenin is a 92-kDa protein, originally identified in cell adherens junctions (AJs) where it functions to bridge the cytoplasmic domain of cadherins to a-catenin and the actin cytoskeleton. Besides its essential role in the AJs, β-catenin is also a key downstream component of the canonical Wnt pathway that plays diverse and critical roles in embryonic development and adult tissue homeostasis. The Wnt/β-catenin pathway is also involved in the activation of other intracellular messengers such as calcium fluxes, JNK, and SRC kinases. Deregulation of β-catenin activity is associated with multiple diseases including cancers. (PMID: 22617422; 18334222)

Specifications

• Antigen: Beta Catenin
• Classification: Polyclonal
• Conjugate: CoraLite 555
• Quantity: 100 μL
• Gene ID (Entrez): 1499
• Form: Liquid

• Applications: Immunofluorescence
• Concentration: 1000 μg/mL
• Host Species: Rabbit
• Primary or Secondary: Primary
• Target Species: Human
• Isotype: IgG