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TCR V beta 8a Monoclonal Antibody (I6G8), Invitrogen™
Mouse Monoclonal Antibody
Brand: Invitrogen TCR1648
Code : PN
Additional Details : Weight : 0.80000kg
Description
TCR1648 targets TCR V beta 8a in FACS, IHC(F), IP, TCA, and WB applications and shows reactivity with Human, and Non-human primate samples. The TCR1648 immunogen is human TCR V beta 8.
The ability of T cell receptors (TCR) to discriminate foreign from self-peptides presented by major histocompatibility complex (MHC) class II molecules is essential for an effective adaptive immune response. TCR recognition of self-peptides has been linked to autoimmune disease. Mutant self-peptides have been associated with tumors. Engagement of TCRs by a family of bacterial toxins know as superantigens has been responsible for toxic shock syndrome. Autoantibodies to V beta segments of T cell receptors have been isolated from patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). The autoantibodies block TH1-mediated inflammatory autodestructive reactions and are believed to be a method by which the immune system compensates for disease (ref5). T Cell and TCR Diversity Most human T cells express the TCR alpha-beta and either CD4 or CD8 molecule (single positive, SP). A small number of T cells lack both CD4 and CD8 (double negative, DN). Increased percentages of alpha-beta DN T cells have been identified in some autoimmune and immunodeficiency disorders. Gamma-delta T cells are primarily found within the epithelium. They show less TCR diversity and recognize antigens differently than alpha-beta T cells. Subsets of gamma-delta T cells have shown antitumor and immunoregulatory activity.Specifications
TCR V beta 8a | |
Monoclonal | |
0.15 mg/mL | |
PBS with 0.5% BSA and 0.1% sodium azide | |
0 | |
TRB | |
Human TCR V beta 8 | |
200 μg | |
Primary | |
Human, Non-human Primate | |
Antibody | |
IgG2b |
Immunocytochemistry, Immunohistochemistry (Frozen), Immunoprecipitation, T-Cell Activation, Western Blot | |
I6G8 | |
Unconjugated | |
TRB | |
T cell receptor beta locus; TCRB; TRB; TRB@ | |
Mouse | |
Protein A | |
RUO | |
6957 | |
-20°C | |
Liquid |