TACR3 Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Brand:  Invitrogen PA534247

Product Code. 15395071

Description

Percent identity with other species by BLAST analysis: Human, Gorilla (100%) Gibbon, Monkey, Bat, Elephant, Rabbit, Pig (94%).

The tachykinins are a family of small peptides that include the neurotransmitters substance P, neurokinin A, and neurokinin B, which can act on three related but distinct seven transmembrane G-proteins coupled receptors, albeit at different concentrations. The NK-3 receptor (NK3R) has greatest affinity for neurokinin B and is highly expressed in the supraoptic and paraventricular nuclei. Following binding of its ligand, NK3R activates a phosphatidylinositol-calcium second messenger system. It is likely these signals lead to the release of vasopressin and oxytocin into the circulation. NK3R may be involved in learning and memory as mice lacking this gene expressed cognitive deficits compared to normal mice. Although it has been suggested that NK3R plays a role in the regulation of vagal afferent relay neurons, it is likely that these receptors are activated by substance P or neurokinin A, as the airway nerves do not express neurokinin B.

Specifications

• Antigen: TACR3
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Tacr3
• Gene Alias: G protein-coupled receptor; HH11; neurokinin 3 receptor; Neurokinin B; neurokinin B receptor; neurokinin beta receptor; neuromedin K receptor; Neuromedin K receptor (Neurokinin B/Tachikin 3); neuromedin-K receptor; Nk3 receptor; NK-3 receptor; NK3R; NK-3R; NK3R TAC3R; Nkr; Nmkr; Nmk-r; TAC3R; TAC3RL; tachikin receptor 3; tachykinin receptor 3; Tacr3
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 6870
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 1 mg/mL
• Formulation: PBS with 0.1% sodium azide
• Gene Accession No.: P29371
• Gene Symbols: Tacr3
• Immunogen: Synthetic 18 amino acid peptide from N-terminal extracellular domain of human TACR3.
• Quantity: 50 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG