SIRT5 Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Brand:  Invitrogen PA531029

Product Code. 13465537

Description

Predicted reactivity: Mouse (90%), Rat (89%), Xenopus laevis (81%), Dog (90%), Pig (89%), Chicken (82%), Bovine (90%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

SIRT5 is a human member of a family of proteins called Sirtuins (Sir2-like proteins) and are present in prokaryotes and eukaryotes. All Sir2-like proteins have a sirtuin core domain, which contains a series of sequence motifs conserved in organisms ranging from bacteria to humans. Bacterial, yeast and mammalian sirtuins are able to metabolize NAD and possibly at as mono-ADP-ribosyltransferases. The enzymatic function of sirtuins is not yet completely understood but recent reports of histone-activated Sir2-mediated NAD metabolism and NAD-activated Sir2-mediated histone deacetylation suggest a possible coupled reciprocal activation mechanism involving interactions of Sir2 with NAD and the N epsilon-acetyl-lysine groups of acetylated histones.

Specifications

• Antigen: SIRT5
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SIRT5
• Gene Alias: 0610012J09Rik; 1500032M05Rik; AV001953; FLJ36950; HAMAP-Rule:MF_03160}; hypothetical protein LOC507347; NAD-dependent deacetylase sirtuin-5; NAD-dependent deacetylase sirtuin-5-like protein; NAD-dependent lysine demalonylase and desuccinylase sirtuin-5, mitochondrial; NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent protein deacylase sirtuin-5, mitochondrial {ECO:0000255; Regulatory protein SIR2 homolog 5; regulatory protein SIR2 homolog 5 {ECO:0000255; si:ch211-121a2.1; silent mating type information regulation 2, S.cerevisiae, homolog 5; Sir2l5; sir2-like 5; SIR2-like protein 5; SIR2-like protein 5 {ECO:0000255; Sirt5; sirtuin; sirtuin 5; sirtuin type 5; zgc:92288
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 23408
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 20% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: Q9NXA8
• Gene Symbols: SIRT5
• Immunogen: Recombinant fragment corresponding to a region within amino acids 9 and 286 of Human SIRT5
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG