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PKCδ Mouse, Unlabeled, Clone: 14, BD

Mouse Monoclonal Antibody

£237.00 - £455.00

Specifications

Antigen PKCδ
Clone 14
Concentration 250μg/mL
Applications Western Blot, Immunohistochemistry, Immunofluorescence
Classification Monoclonal
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Products 2
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
15815439
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BD Biosciences
610397
50 μg
£237.00
1 set
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Estimated Shipment: 03-06-2024
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15825439
View Documents Promotion Details
BD Biosciences
610398
150 μg
£455.00
1 set
View alternative products
Save Up to 
»
Estimated Shipment: 03-06-2024
to see stock.
Please to purchase this item. Need a web account? Register with us today!
Description

Description

The Protein Kinase C (PKC) family of homologous serine/threonine protein kinases. At least eleven isozymes have been described. These proteins are products of multiple genes and alternative splicing. PKC consists of a single polypeptide chain containing four conserved regions (C) and five variable regions (V). The N-terminal half containing C1, C2, V1, and V2 constitutes the regulatory domain and interacts withPKC activators Ca2+, phospholipid, diacylglycerol, or phorbol ester. However, the novel PKC (nPKC) subfamily members (δ, ε, η and θ isoforms) and the atypical PKC (aPKC) subfamily members (ζ, ι, and λ isoforms) are Ca2+ independent and lack the C2 domain. The aPKC members are unique in that their activity is independent of diacylglycerols and phorbol esters. They also lack one repeat of the cysteine-rich sequences that are conserved in cPKC and nPKC. The C-terminal region of PKC contains the catalytic domain. PKCδ is involved in myeloid differentiation, as well as in the secretory response of antigen-stimulated rat basophilic RBL 2H3 cells. Overexpression and subsequent stimulation of PKCδ leads to cell cycle arrest in CHO cells and complete growth inhibition of NIH 3T3 cells. PKCδ is the most abundant isoform in hemopoietic cells and is highly expressed in many other organs and tissues. This suggests that PKCδ may be one of the major PKC isozymes in mammalian cells.

This antibody is routinely tested by Western blot analysis. Other applications were tested at BD Biosciences Pharmingen during antibody development only or reported in the literature.

Specifications

Specifications

PKCδ
250μg/mL
Monoclonal
Mouse
Cell Biology
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
IgG2b
Affinity Purified
14
Western Blot, Immunohistochemistry, Immunofluorescence
Unconjugated
RUO
Human, Mouse, Rat
Human PKCδ aa. 114-289
Primary
Store undiluted at -20°C.
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For Research Use Only.