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PIWIL2 Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Brand:  Invitrogen PA534341

Product Code. 15375261

  • £404.00 / 100µg

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Description

Description

A suggested positive control is human brain tissue lysate. PA5-34341 can be used with blocking peptide PEP-1384.

The piwi gene of Drosophila belongs to a novel class of evolutionarily conserved genes (the piwi or Argonaute family). The Piwi family is required for germ and stem cell development in invertebrates, and two Piwi members, MIWI and MILI (Miwi like, Piwil2, Piwi-like protein 2), are essential for spermatogenesis in mouse. MIWI and MILI partner with Piwi-interacting RNAs (piRNAs) which are 26-31 nucleotides in length clearly distinct from the 21-23 nucleotides of microRNAs (miRNAs) or short interfering RNAs (siRNAs). A search for murine small RNAs that might program Piwi proteins for transposon suppression revealed developmentally regulated piRNA loci, some of which resemble transposon master control loci of Drosophila. MILI might be programmed by distinct piRNA populations at different stages of germ cell development, suggesting MILI plays an important role in meiotic prophase progression.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

PIWIL2
Polyclonal
Unconjugated
Piwil2
80kDa PIWIL2 short isoform; cancer/testis antigen 80; CT80; HILI; mili; Miwi like; Miwi likw; piwi like homolog 2; piwi like RNA-mediated gene silencing 2; PIWIL1L; Piwil2; PIWI-L2; piwil2-like protein; piwi-like 2; piwi-like homolog 2; piwi-like protein 2; piwi-like RNA-mediated gene silencing 2; testicular tissue protein Li 141
Rabbit
Antigen affinity chromatography
RUO
55124
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Liquid
Immunohistochemistry
1 mg/mL
PBS with 0.02% sodium azide
Q8TC59
Piwil2
A 14 amino acid synthetic peptide near the center of human PIWI-L2
100 μg
Primary
Human
Antibody
IgG
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