GLP-1 Monoclonal Antibody (10), Invitrogen™

Mouse Monoclonal Antibody

Brand:  Invitrogen ABS0331002

Product Code. 11524142

Description

ABS 033-10-02 detects the amidated N-terminus of GLP-1(7-37) and GLP-1(7-36) in human samples. ABS 033-10-02 has been successfully used in ELISA procedures. ABS 033-10-02 binds the free N-terminus of GLP-1(7-37) and GLP-1(7-36)amide and shows <0.2% cross-reactivity with GLP-1(9-36)amide, glucagon and human GIP. Cross-reacts 0.25% with GLP-1(1-37), approximately 6% with human GLP-2 and approximately 50% with exendin-4. NOTE: Concentration is lot-dependent and can vary from 0.85-1.15 mg/mL

GCG is also known as GLP1, or Glucagon. Glucagon is a 29-amino acid pancreatic hormone that counteracts the glucose-lowering action of insulin by stimulating glycogenolysis and gluconeogenesis.It is mapped to 2q36-2q37. GLP1, also known as 7-37 for the codons of the preproglucagon molecule which encode it, renders pancreatic beta-cells 'glucose-competent' and may be useful in the treatment of noninsulin-dependent diabetes mellitus. Also, GLP1 is a potent insulin secretagogue.It plays a major role in the enteroinsular axis, accounting, for example, for the finding that plasma insulin levels accompanying oral intake of glucose are greater than those observed when glucose is given intravenously.

Specifications

• Antigen: GLP-1
• Classification: Monoclonal
• Concentration: 0.99 mg/mL
• Formulation: PBS with 15mM sodium azide; pH 7.4
• Gene Accession No.: P01275
• Gene Symbols: GCG
• Immunogen: Synthetic glucagon-like peptide-1 (7-17) adsorbed into aluminum hydroxide gel.
• Quantity: 400 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2a κ

• Applications: ELISA
• Clone: 10
• Conjugate: Unconjugated
• Gene: GCG
• Gene Alias: GCG; Glicentin; Glicentin-related polypeptide; GLP1; GLP-1; GLP-1(7-36); GLP-1(7-37); GLP1/2; GLP2; GLP-2; Glu; glucagon; Glucagon like peptide 1; Glucagon-like peptide 1; Glucagon-like peptide 1(7-36); Glucagon-like peptide 1(7-37); Glucagon-like peptide 2; glucagon-like peptide-1; GRPP; Incretin hormone; MGC138331; OXM; OXY; Oxyntomodulin; PPG; preproglucagon
• Host Species: Mouse
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 2641
• Content And Storage: 4° C, store in dark
• Form: Liquid