(7-Aza-1H-benzotriazol-1-yloxy)tri(1-pyrrolidinyl)phosphonium hexafluorophosphate, 99+%, Thermo Scientific Chemicals

Product Code	Brand	Quantity
15485265	Thermo Scientific Alfa Aesar H54378.03	1 g
15495265	Thermo Scientific Alfa Aesar H54378.06	5 g

Description

(7-Aza-1H-benzotriazol-1-yloxy)tri(1-pyrrolidinyl)phosphonium hexafluorophosphate is used as reagent for synthesis of cyclic RGC pentapeptides for functionalization through click chemistry, fluorescent glucose bioprobes and ReactIR™ flow cell. It is also used as reagent for disulfide bond engineering, heteroaryl ether synthesis and optimization of conformational constraint on non-phosphorylated cyclic peptide antagonists of the Grb2-SH2 domain.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
(7-Aza-1H-benzotriazol-1-yloxy)tri(1-pyrrolidinyl)phosphonium hexafluorophosphate is used as reagent for synthesis of cyclic RGC pentapeptides for functionalization through click chemistry, fluorescent glucose bioprobes and ReactIR™ flow cell. It is also used as reagent for disulfide bond engineering, heteroaryl ether synthesis and optimization of conformational constraint on non-phosphorylated cyclic peptide antagonists of the Grb2-SH2 domain.

Solubility
Soluble in water.

Notes
Stable under recommended storage conditions. Store away from oxidizing agents.

Chemical Identifiers

• CAS: 156311-83-0
• Molecular Weight (g/mol): 521.39
• InChI Key: CBZAHNDHLWAZQC-UHFFFAOYSA-N
• PubChem CID: 11038641
• SMILES: F[P-](F)(F)(F)(F)F.C1CCN(C1)[P+](ON1N=NC2=CC=CN=C12)(N1CCCC1)N1CCCC1

• Molecular Formula: C17H27F6N7OP2
• MDL Number: MFCD03703417
• Synonym: pyaop, 3h-1,2,3 triazolo 4,5-b pyridin-3-yl oxy tri pyrrolidin-1-yl phosphonium hexafluorophosphate v, 7-azabenzotriazol-1-yloxy tripyrrolidinophosphonium hexafluorophosphate, 3-hydroxy-3h-1,2,3-triazolo 4,5-b pyridinato-o tri-1-pyrrolidinylphosphonium hexafluorophosphate, pyaop reagent, 7-azabenzotriazol-1-yloxy tripyrrolidino-phosphonium hexafluorophosphate, 7-azabenzotriazol-1-yloxy-tris-pyrrolidino phosphonium hexafluorophosphate, pubchem12746, ksc491e1h
• IUPAC Name: tripyrrolidin-1-yl(triazolo[4,5-b]pyridin-3-yloxy)phosphanium;hexafluorophosphate

Specifications

• CAS: 156311-83-0
• Molecular Formula: C17H27F6N7OP2
• Synonym: pyaop, 3h-1,2,3 triazolo 4,5-b pyridin-3-yl oxy tri pyrrolidin-1-yl phosphonium hexafluorophosphate v, 7-azabenzotriazol-1-yloxy tripyrrolidinophosphonium hexafluorophosphate, 3-hydroxy-3h-1,2,3-triazolo 4,5-b pyridinato-o tri-1-pyrrolidinylphosphonium hexafluorophosphate, pyaop reagent, 7-azabenzotriazol-1-yloxy tripyrrolidino-phosphonium hexafluorophosphate, 7-azabenzotriazol-1-yloxy-tris-pyrrolidino phosphonium hexafluorophosphate, pubchem12746, ksc491e1h
• InChI Key: CBZAHNDHLWAZQC-UHFFFAOYSA-N
• IUPAC Name: tripyrrolidin-1-yl(triazolo[4,5-b]pyridin-3-yloxy)phosphanium;hexafluorophosphate
• PubChem CID: 11038641
• Percent Purity: ≥99%

• Melting Point: 163°C to 168°C
• MDL Number: MFCD03703417
• Solubility Information: Soluble in water.
• SMILES: F[P-](F)(F)(F)(F)F.C1CCN(C1)[P+](ON1N=NC2=CC=CN=C12)(N1CCCC1)N1CCCC1
• Molecular Weight (g/mol): 521.39
• Formula Weight: 521.38
• Chemical Name or Material: (7-Aza-1H-benzotriazol-1-yloxy)tri(1-pyrrolidinyl)phosphonium hexafluorophosphate

Safety and Handling

GHS H Statement
H315-H319-H335
Causes skin irritation.
Causes serious eye irritation.
May cause respiratory irritation.

P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P362-P501c

H315-H319-H335

missing translation for 'rtecsNumber' : TH3890000

missing translation for 'tsca' : No

Recommended Storage : Ambient temperatures

RUO – Research Use Only