1-Trimethylsilylmethanol, 95%, Thermo Scientific Chemicals

Product Code	Brand	Quantity
11396856	Thermo Scientific Alfa Aesar L04251.03	1 g
11306866	Thermo Scientific Alfa Aesar L04251.06	5 g

Description

1-Trimethylsilylmethanol is used as nucleophile to resolve the racemate obtained from enantioselective esterification of naproxen (2-(6-methoxy-2-naphthyl) propionic acid) by lipases. It was also used as a nucleophilic hydroxymethylation agent.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
1-Trimethylsilylmethanol is used as nucleophile to resolve the racemate obtained from enantioselective esterification of naproxen (2-(6-methoxy-2-naphthyl) propionic acid) by lipases. It was also used as a nucleophilic hydroxymethylation agent.

Solubility
Fully miscible in water.

Notes
Store at 4°C. Incompatible with oxidizing agents. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

Chemical Identifiers

• CAS: 3219-63-4
• Molecular Weight (g/mol): 104.224
• InChI Key: ZQKNBDOVPOZPLY-UHFFFAOYSA-N
• PubChem CID: 76692
• SMILES: C[Si](C)(C)CO

• Molecular Formula: C4H12OSi
• MDL Number: MFCD00004596
• Synonym: trimethylsilyl methanol, 1-trimethylsilylmethanol, hydroxymethyltrimethylsilane, methanol, trimethylsilyl, silane, hydroxymethyl trimethyl, hydroxymethyl trimethylsilane, trimethylhydroxymethylsilane, methanol, 1-trimethylsilyl, trimethylsilyl-methanol, acmc-209hrr
• IUPAC Name: trimethylsilylmethanol

Specifications

• Boiling Point: 121°C to 122°C
• Molecular Formula: C4H12OSi
• UN Number: UN1993
• Flash Point: 31°C (87°F)
• Solubility Information: Fully miscible in water.
• SMILES: C[Si](C)(C)CO
• Molecular Weight (g/mol): 104.224
• Formula Weight: 104.23
• Refractive Index: 1.419
• Chemical Name or Material: 1-Trimethylsilylmethanol

• CAS: 3219-63-4
• MDL Number: MFCD00004596
• Beilstein: 1731486
• Synonym: trimethylsilyl methanol, 1-trimethylsilylmethanol, hydroxymethyltrimethylsilane, methanol, trimethylsilyl, silane, hydroxymethyl trimethyl, hydroxymethyl trimethylsilane, trimethylhydroxymethylsilane, methanol, 1-trimethylsilyl, trimethylsilyl-methanol, acmc-209hrr
• InChI Key: ZQKNBDOVPOZPLY-UHFFFAOYSA-N
• IUPAC Name: trimethylsilylmethanol
• PubChem CID: 76692
• Percent Purity: ≥98%
• Density: 0.827

Safety and Handling

GHS H Statement
H226
Flammable liquid and vapor.

P210-P233-P240-P241-P242-P243-P280-P303+P361+P353-P370+P378q-P501c

H226

missing translation for 'dotInformation' : Transport Hazard Class: 3; Packing Group: III; Proper Shipping Name: FLAMMABLE LIQUIDS, N.O.S.

missing translation for 'einecsNumber' : 221-746-5

missing translation for 'rtecsNumber' : PC4100000

missing translation for 'tsca' : Yes

Recommended Storage : Ambient temperatures

RUO – Research Use Only