1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride, 98+%, Thermo Scientific Chemicals

Product Code	Brand	Quantity
11409742	Thermo Scientific Alfa Aesar A10807.03	1 g
11419742	Thermo Scientific Alfa Aesar A10807.06	5 g
11429742	Thermo Scientific Alfa Aesar A10807.14	25 g

Description

1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride is used as a carboxyl activating agent. It is used in peptide synthesis, 3'-amino-3'-deoxyadenosine-5'-di- and triphosphates and in the preparation of antibodies like immunoconjugates. It plays a vital role for immobilization of large biomolecules in association with N-hydroxysuccinimide. It is also used in the acylation of phosphoranes.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride is used as a carboxyl activating agent. It is used in peptide synthesis, 3′-amino-3′-deoxyadenosine-5′-di- and triphosphates and in the preparation of antibodies like immunoconjugates. It plays a vital role for immobilization of large biomolecules in association with N-hydroxysuccinimide. It is also used in the acylation of phosphoranes.

Solubility
Soluble in acetonitrile dichloromethane, dimethylformamide, and tetrahydrofuran. Slightly soluble in water.

Notes
Sensitive to moisture. Incompatible with strong acids, strong oxidizing agents and moisture.

Chemical Identifiers

• CAS: 25952-53-8
• Molecular Weight (g/mol): 191.70
• InChI Key: FPQQSJJWHUJYPU-UHFFFAOYSA-N
• PubChem CID: 2723939
• SMILES: Cl.CCN=C=NCCCN(C)C

• Molecular Formula: C8H18ClN3
• MDL Number: MFCD00012503
• Synonym: 1-3-dimethylaminopropyl-3-ethylcarbodiimide hydrochloride, edc.hcl, edci, edc hydrochloride, wsc hcl, edac hydrochloride, edac, hydrochloride, 1-ethyl-3-3-dimethylaminopropyl carbodiimide hydrochloride, edcl, edac hcl
• IUPAC Name: 3-(ethyliminomethylideneamino)-N,N-dimethylpropan-1-amine;hydrochloride

Specifications

• CAS: 25952-53-8
• Molecular Formula: C8H18ClN3
• MDL Number: MFCD00012503
• Sensitivity: Moisture sensitive
• Solubility Information: Soluble in acetonitrile dichloromethane,dimethylformamide,and tetrahydrofuran. Slightly soluble in water.
• SMILES: Cl.CCN=C=NCCCN(C)C
• Molecular Weight (g/mol): 191.70
• Formula Weight: 191.7
• Chemical Name or Material: 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride

• Melting Point: ∽113°C
• Linear Formula: CH₃CH₂N=C=N(CH₂)₃N(CH₃)₂·HCl
• Beilstein: 5764110
• Synonym: 1-3-dimethylaminopropyl-3-ethylcarbodiimide hydrochloride, edc.hcl, edci, edc hydrochloride, wsc hcl, edac hydrochloride, edac, hydrochloride, 1-ethyl-3-3-dimethylaminopropyl carbodiimide hydrochloride, edcl, edac hcl
• InChI Key: FPQQSJJWHUJYPU-UHFFFAOYSA-N
• IUPAC Name: 3-(ethyliminomethylideneamino)-N,N-dimethylpropan-1-amine;hydrochloride
• PubChem CID: 2723939
• Percent Purity: ≥98%

Safety and Handling

GHS H Statement
H315-H319-H335
Causes skin irritation.
Causes serious eye irritation.
May cause respiratory irritation.

P261-P264b-P270-P272-P280-P301+P312-P302+P352-P305+P351+P338-P330-P333+P313-P362-P501c

H302-H315-H317-H319

missing translation for 'dotInformation' : Hazard Class: 9; Packaging Group: III

missing translation for 'einecsNumber' : 247-361-2

missing translation for 'rtecsNumber' : FF2200000

missing translation for 'tsca' : Yes

Recommended Storage : Keep cold

Product Identifier

• 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimidehydrochloride

Signal Word

• Danger

Hazard Category

• Acute toxicity Category 3
• Acute toxicity Category 4
• LONG-TERM AQUATIC HAZARD Chronic 1
• ACUTE AQUATIC Acute 1
• Serious eye damage/eye irritation Category 2
• Skin corrosion/irritation Category 2
• Skin sensitiser Category 1
• Specific target organ toxicity after repeated exposure Category 2

Hazard Statement

• H302-Harmful if swallowed.
• H311-Toxic in contact with skin.
• H315-Causes skin irritation.
• H317-May cause an allergic skin reaction.
• H319-Causes serious eye irritation.
• H373-May cause damage to organs.
• H400-Very toxic to aquatic life.
• H410-Very toxic to aquatic life with long lasting effects.

Precautionary Statement

• P280-Wear protective gloves/protective clothing/eye protection/face protection.
• P301+P330+P331-IF SWALLOWED: rinse mouth. Do NOT induce vomiting.
• P302+P352-IF ON SKIN: Wash with plenty of water/soap.
• P305+P351+P338-IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
• P312-Call a POISON CENTER/doctor/if you feel unwell.

Supplemental information

• MIXTURE LIST-Contains : 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimidehydrochloride

RUO – Research Use Only