Methanesulfonyl chloride, 98%, Thermo Scientific Chemicals

Product Code	Brand	Quantity
11660212	Thermo Scientific Alfa Aesar A13383.22	100 g
11491930	Thermo Scientific Alfa Aesar A13383.36	500 g

Description

Methanesulfonyl chloride is used as a reagent for conversion of alcohols to mesylate esters such as methanesulfonate, which is an intermediate in substitution reactions, elimination reactions, reductions, and rearrangement reactions viz. Beckmann rearrangement. It is an electrophile and acts as a source of CH₃SO₂⁺ group. It is also used to prepare beta-chloro sulfones, methanesulfonamide and heterocyclic compounds containing five membered sultones.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Methanesulfonyl chloride is used as a reagent for conversion of alcohols to mesylate esters such as methanesulfonate, which is an intermediate in substitution reactions, elimination reactions, reductions, and rearrangement reactions viz. Beckmann rearrangement. It is an electrophile and acts as a source of CH₃SO₂⁺ group. It is also used to prepare beta-chloro sulfones, methanesulfonamide and heterocyclic compounds containing five membered sultones.

Solubility
Miscible with alcohol, ether and organic solvents. Immiscible with water.

Notes
Moisture sensitive. Store in a cool place. Incompatible with strong bases, oxidizing agents and alcohols. It is a lachrymator and reacts with water.

Chemical Identifiers

• CAS: 124-63-0
• Molecular Weight (g/mol): 114.54
• InChI Key: QARBMVPHQWIHKH-UHFFFAOYSA-N
• PubChem CID: 31297
• SMILES: CS(Cl)(=O)=O

• Molecular Formula: CH3ClO2S
• MDL Number: MFCD00007454
• Synonym: mesyl chloride, methylsulfonyl chloride, methyl sulfochloride, methanesulphonyl chloride, chloro methyl sulfone, methanesulfuryl chloride, methanesulfonic acid chloride, methyl sulfonyl chloride, chloromethyl sulfone, mesylchloride
• IUPAC Name: methanesulfonyl chloride

Specifications

• CAS: 124-63-0
• Density: 1.477
• Flash Point: 97°C (206°F)
• Molecular Formula: CH3ClO2S
• MDL Number: MFCD00007454
• Beilstein: 506297
• Merck Index: 14,5955
• Solubility Information: Miscible with alcohol,ether and organic solvents. Immiscible with water.
• SMILES: CS(Cl)(=O)=O
• Molecular Weight (g/mol): 114.54
• Formula Weight: 114.55
• Physical Form: Liquid

• Melting Point: °C to 33°C
• Boiling Point: 161°C
• Assay Percent Range: 98%
• Refractive Index: 1.452
• UN Number: UN3246
• Sensitivity: Moisture sensitive
• Synonym: mesyl chloride, methylsulfonyl chloride, methyl sulfochloride, methanesulphonyl chloride, chloro methyl sulfone, methanesulfuryl chloride, methanesulfonic acid chloride, methyl sulfonyl chloride, chloromethyl sulfone, mesylchloride
• InChI Key: QARBMVPHQWIHKH-UHFFFAOYSA-N
• IUPAC Name: methanesulfonyl chloride
• PubChem CID: 31297
• Percent Purity: 98%
• Chemical Name or Material: Methanesulfonyl Chloride

Safety and Handling

GHS H Statement
H300-H310-H330-H314-H318

P234-P260-P264b-P270-P271-P272-P280-P284-P303+P361+P353-P304+P340-P305+P351+P338-P310-P330-P331-P333+P313-P363-P390-P501c

H290-H301+H311-H314-H317-H330-H335

missing translation for 'dotInformation' : Transport Hazard Class: 6.1; Packing Group: I; Proper Shipping Name: METHANESULFONYL CHLORIDE

missing translation for 'einecsNumber' : 204-706-1

missing translation for 'rtecsNumber' : PB2790000

missing translation for 'tsca' : Yes

missing translation for 'storageNote' : Moisture Sensitive

Recommended Storage : Ambient temperatures

Product Identifier

• Methanesulfonyl chloride

Signal Word

• Danger

Hazard Category

• Acute toxicity Category 1
• Acute toxicity Category 3
• Serious eye damage/eye irritation Category 1
• Substances and mixtures corrosive to metals Category 1
• Skin corrosion/irritation Category 1 B
• Skin sensitiser Category 1
• Specific target organ toxicity Category 3

Hazard Statement

• H290-May be corrosive to metals.
• H301-Toxic if swallowed.
• H311-Toxic in contact with skin.
• H314-Causes severe skin burns and eye damage.
• H317-May cause an allergic skin reaction.
• H318-Causes serious eye damage.
• H330-Fatal if inhaled.
• H335-May cause respiratory irritation.

Precautionary Statement

• P280-Wear protective gloves/protective clothing/eye protection/face protection.
• P301+P330+P331-IF SWALLOWED: rinse mouth. Do NOT induce vomiting.
• P303+P361+P353-IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water/ shower.
• P304+P340-IF INHALED: Remove person to fresh air and keep comfortable for breathing.
• P305+P351+P338-IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
• P310-Immediately call a POISON CENTER/doctor/.

Supplemental information

• MIXTURE LIST-Contains : Methanesulfonyl chloride

RUO – Research Use Only