Human LRRK2 [G2019S], GST Tag Recombinant Protein

LRRK2 is a multidomain protein that includes a kinase domain, a GTPase domain, and a leucine-rich repeat (LRR) domain.

Brand:  Invitrogen PV4881

Product Code. 10499963

Description

Mutations in the LRRK2 gene have been associated with Parkinson's disease. The G2019S mutation of LRRK2 is associated with an increase in catalytic activity.

Specifications

• Accession Number: NP_940980.2, G2019S
• Gene ID (Entrez): 120892
• Quantity: 10μg
• KinaseFamily: LRRK Kinase Family
• Species: Human
• Protein Tag: GST Tag
• Assay Entry: Biochemical ADP accumulation, Biochemical terbium phospho-specific activity, Biochemical binding/kinetic
• Shipping Condition: Dry Ice
• Target Entry: LRRK2 G2019S
• Expression System: Baculovirus
• Protein Form: Recombinant, Catalytic, Mutant
• Protein Subtype: Serine/Threonine Kinases

• For Use With (Application): Kinase Assay
• Molecular Weight (g/mol): 204.9 kDa
• Gene Alias: LRRK2 G2019S
• Protein Length: aa 970-2527; G2019S
• Recombinant: Recombinant
• Content And Storage: Storage Buffer: 50 mM Tris pH 7.5, 150 mM NaCl, 0.5 mM EDTA, 0.02% Polysorbate 20, 2 mM DTT, 50% glycerol
  Store at -80°C. At first use, aliquot and store at -80°C to avoid multiple freeze-thaws.
• Kinase Group: Ser⁄Thr Kinases: TKL Group
• System Compatibility: LanthaScreen™ Antibody, LanthaScreen™ Substrate, Adapta™
• Target Gene: Leucine-rich repeat kinase 2
• Protein Family: Kinases & Inhibitors
• Form: Liquid
• Research Category: Signal Transduction, Neurobiology