Invitrogen™ LRRK2 [G2019S] Recombinant Protein

Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene, which codes for a multidomain protein kinase, are considered the most common genetic cause of late-onset autosomal-dominant Parkinson's disease.

Brand:  Invitrogen™ A15202

Product Code. 15468363

Description

This full-length, purified and active LRRK2 G2019S mutant protein may be useful in research to better understand the most common Parkinson's disease-relevant mutant, as well as to explore the mechanisms underlying the disease.

• Increase disease relevance by interrogating a purified and active full-length LRRK2 protein
• Uncover novel compounds or hits specific to the full-length form
• Advance Parkinson 's research using the full-length protein and validated assays

Specifications

• Accession Number: NP_940980.3
• Molecular Weight (g/mol): 288 kDa
• Gene Alias: AURA17, DARDARIN, PARK8, RIPK7, ROCO2
• Species: Human
• Content And Storage: Store at -68 to -85°C. Aliquot at first use to avoid multiple freeze-thaws. If properly stored, this product is guaranteed for 6 months from date of purchase.
  
  Suspended in: 50 mM Tris (pH 7.5), 150 mM NaCl, 0.5 mM EDTA, 0.02% Triton™X–100, 2 mM DTT, and 50% glycerol.
• Protein Family: Kinases & Inhibitors
• Form: Liquid

• For Use With (Application): Kinase Assay
• Quantity: 1mg
• KinaseFamily: LRRK Kinase Family
• Protein Tag: DYKDDDDK
• Expression System: Mammalian
• Protein Form: Recombinant, Full Length, Mutant
• Research Category: Neurobiology