Thermo Scientific Chemicals Leupeptin hemisulfate

Description

Reversible protease inhibitor which inhibits cathepsin B, calpain and trypsin

Reversible protease inhibitor, which inhibits cathepsin B, calpain and trypsinPharmaceutical composition containing leupeptin hemisulfate is used as an anti-malarial agent. It is employed in the treatment of noise-induced hearing loss. It also protects the heart from myocardial stunning. Further, it is used to inhibit serine, cysteine proteases, plasmin, trypsin, papain, kallikrein and cathepsin B.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Reversible protease inhibitor, which inhibits cathepsin B, calpain and trypsinPharmaceutical composition containing leupeptin hemisulfate is used as an anti-malarial agent. It is employed in the treatment of noise-induced hearing loss. It also protects the heart from myocardial stunning. Further, it is used to inhibit serine, cysteine proteases, plasmin, trypsin, papain, kallikrein and cathepsin B.

Solubility
Soluble in water, ethanol, dimethyl formamide and acetic acid.

Notes
Store in a cool place. Incompatible with strong acids and strong bases.

Specifications

Chemical Identifiers

• CAS: 103476-89-7
• Molecular Formula: C20H39N6O4+

• Color: White
• Product Type: Leupeptin
• Formula Weight: 475.59
• Solubility: Soluble in water at 50mg/ml
• Content And Storage: -30°C to -10°C
• Form: Powder
• Quantity: 100 mg

Safety and Handling

Product Identifier

• Leupeptin hemisulfate

Signal Word

• Warning

Hazard Category

• Acute toxicity Category 4

Hazard Statement

• H302-Harmful if swallowed.
• H312-Harmful in contact with skin.
• H332-Harmful if inhaled.

Precautionary Statement

• P280-Wear protective gloves/protective clothing/eye protection/face protection.
• P301+P330+P331-IF SWALLOWED: rinse mouth. Do NOT induce vomiting.
• P302+P352-IF ON SKIN: Wash with plenty of water/soap.
• P304+P340-IF INHALED: Remove person to fresh air and keep comfortable for breathing.
• P312-Call a POISON CENTER/doctor/if you feel unwell.

Supplemental information

• MIXTURE LIST-Contains : Leupeptin hemisulfate

RUO – Research Use Only