Thermo Scientific Chemicals Ionomycin, 96%

Product Code	Brand	Quantity
15414829	Thermo Scientific Chemicals J62448.M^	1 mg
15404829	Thermo Scientific Chemicals J62448.#0	5 mg

Description

Ionomycin free acid is a beneficial tool in research to raise intracellular calcium levels. Also this antibiotic can be used to study the calcium transport across the plasma membrane. It has been shown to induce central demyelination , inhibit adrenal bovine TREK-1 channels , and to regulate cell division of mature human B cells . It is used to study the effects of calcium flux on endoplasmic reticulum (ER) stress, mitochondrial stress and intrinsic apoptosis mechanisms. It is also used to stimulate the intracellular production of the cytokines, interferon, perforin, IL-2, and IL-4 usually in conjunction with PMA.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Chemical Identifiers

• CAS: 56092-81-0
• Molecular Formula: C41H72O9

Specifications

• Description: Colorless
• For Use With (Application): Highly selective and potent calcium ionophore
• Molecular Formula: C41H72O9
• Odor: Alcohol-like
• Form: Solution in ethanol
• InChI Key: PGHMRUGBZOYCAA-OJFQOPKISA-N
• IUPAC Name: (4R,6S,8S,10Z,12R,14R,16E,18R,19R,20S,21S)-11,19,21-trihydroxy-22-[(2S,5'S)-5'-[(1R)-1-hydroxyethyl]-2,5'-dimethyl-[2,2'-bioxolan]-5-yl]-4,6,8,12,14,18,20-heptamethyl-9-oxodocosa-10,16-dienoic acid
• Assay: 98%

• Content And Storage: -30°C to -10°C
• CAS: 56092-81-0
• Formula Weight: 709.02
• Product Type: Ionomycin
• Beilstein: 3642126
• SMILES: C[C@H](CCC(O)=O)C[C@H](C)C[C@H](C)C(=O)\C=C(/O)[C@H](C)C[C@H](C)C\C=C\[C@@H](C)[C@@H](O)[C@@H](C)[C@@H](O)CC1CC[C@](C)(O1)C1CC[C@](C)(O1)[C@@H](C)O
• Molecular Weight (g/mol): 709.02

Safety and Handling

Recommended Storage : Store at -20°C

Product Identifier

• Ionomycin

Signal Word

• Danger

Hazard Category

• Serious eye damage/eye irritation Category 2
• Flammable liquid Category 2

Hazard Statement

• H225-Highly flammable liquid and vapour.
• H319-Causes serious eye irritation.

Precautionary Statement

• P210-Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.
• P264-Wash face, hands and anyexposed skin thoroughly after handling.
• P280-Wear protective gloves/protective clothing/eye protection/face protection.
• P303+P361+P353-IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water/ shower.
• P305+P351+P338-IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
• P337+P313-If eye irritation persists: Get medical advice/attention.

Supplemental information

• MIXTURE LIST-Contains : ethanol, ionomycin

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RUO – Research Use Only