Hypoxanthine, 99%, Thermo Scientific Chemicals

Description

Hypoxanthine, is used as a marker for energy perturbation in hypoxia/ ischemia. It has been also used in DNA studies to investigate the destabilizing effect it has on DNA duplexes containing hypoxanthine as a base, in a gas phase versus a liquid phase. Hypoxanthine has also been used in studies along with 8-oxoguanine nucleotides to investigate their interaction with human DNA pol A (DNA polymerase alpha) and DNA polymerase I from Bacillus stearothermophilus. It is also used as a pharmaceutical intermediate.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Hypoxanthine, is used as a marker for energy perturbation in hypoxia/ ischemia. It has been also used in DNA studies to investigate the destabilizing effect it has on DNA duplexes containing hypoxanthine as a base, in a gas phase versus a liquid phase. Hypoxanthine has also been used in studies along with 8-oxoguanine nucleotides to investigate their interaction with human DNA pol å (DNA polymerase alpha) and DNA polymerase I from Bacillus stearothermophilus. It is also used as a pharmaceutical intermediate.

Solubility
It does not mix appreciably with water (1:1400). Small octahedra crystals from water.

Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Incompatible to Strong oxidizing agents. Stable under recommended storage conditions. Sterilize by filtration through a 0.22 µm filter.

Specifications

Chemical Identifiers

• CAS: 68-94-0
• Molecular Formula: C5H4N4O
• Molecular Weight (g/mol): 136.11
• MDL Number: MFCD00005725
• InChI Key: FDGQSTZJBFJUBT-UHFFFAOYSA-N
• Synonym: hypoxanthine, 6-hydroxypurine, 9h-purin-6-ol, sarkin, 6-oxopurine, sarcine, sarkine, 3h-purin-6-ol, 7h-purin-6-ol, purin-6 1h-one
• PubChem CID: 790
• ChEBI: CHEBI:17368
• IUPAC Name: 3,7-dihydropurin-6-one
• SMILES: O=C1N=CNC2=C1NC=N2

• Melting Point: >300°C
• Quantity: 5 g
• Beilstein: 5811
• Merck Index: 14,4869
• Solubility Information: It does not mix appreciably with water (1:1400). Small octahedra crystals from water.
• Formula Weight: 136.11
• Percent Purity: 99%
• Chemical Name or Material: Hypoxanthine

Safety and Handling

Product Identifier

• Hypoxanthine

Signal Word

• Warning

Hazard Category

• Acute toxicity Category 4
• Serious eye damage/eye irritation Category 2
• Skin corrosion/irritation Category 2
• Specific target organ toxicity Category 3

Hazard Statement

• H302-Harmful if swallowed.
• H315-Causes skin irritation.
• H319-Causes serious eye irritation.
• H335-May cause respiratory irritation.

Precautionary Statement

• P261-Avoid breathing dust/fume/gas/mist/vapours/spray.
• P280-Wear protective gloves/protective clothing/eye protection/face protection.
• P301+P312-IF SWALLOWED: Call a POISON CENTER or doctor/physician/ if you feel unwell.
• P302+P352-IF ON SKIN: Wash with plenty of water/soap.
• P305+P351+P338-IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Supplemental information

• MIXTURE LIST-Contains : Hypoxanthine

RUO – Research Use Only