HSP701L Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Brand:  Thermo Scientific PA560310

Product Code. 15788141

Description

Immunogen sequence: KLYQGGCTGP ACGTGYVPGR PATGPTIEEV D Highest antigen sequence identity to the following orthologs: Mouse - 81%, Rat - 81%.

In response to adverse changes in their environment, cells from many organisms increase the expression of a class of proteins referred to as heat shock proteins. One class of stress proteins, termed the "e;small heat shock proteins"e; is comprised of a diverse group of proteins from approximately15 to >30 kDa, with a single form found in yeast and human cells and multiple related forms found in higher plants. A direct relationship between elevated strwess protein expression and neoplasia has been suggested from studies on estrogen-induced proteins in breast cancer cells. In addition, Hsp27 exhibits rapid increased phosphorylation in response to various mitogens, tumor promoter (e. g. phorbol esters) and calcium ionophores. The expression of a 24 kDa protein was shown to correlate with steroid hormone receptor in cell lines, organs, and tumors. The 24 kDa estrogen-induced protein was found to be expressed at high levels in carcinoma of the breast. Another study has suggested that levels of the Hsp27 correlate with endometrial adenocarcinomas. Interestingly, the regulation of human Hsp27 by estrogens and heat shock is reminiscent of the ecdysteroid and heat shock activation of the drosophila Hsp20 genes.

Specifications

• Antigen: HSP701L
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Hspa1l
• Gene Alias: heat shock 10kDa protein 1-like; heat shock 70 kDa protein 1-Hom; heat shock 70 kDa protein 1L; Heat shock 70 kDa protein 1-like; Heat shock 70 kDa protein 3; heat shock 70 kDa-like protein 1; heat shock 70kD protein-like 1; heat shock 70kDa protein 1-like; Heat shock protein; heat shock protein 1-like; Heat shock protein 70-1l; heat shock protein cognate 70, testis; heat shock protein family A (Hsp70) member 1 like; heat shock-related protein hsc70t; Hsc70t; HSP70.3; HSP70-1L; Hsp70-3; HSP70-HOM; HSP70T; Hspa1l; hum70t; inducible heat shock protein 70; Msh5; Spermatid-specific heat shock protein 70
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 15482, 24963, 3305
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry, Western Blot
• Concentration: 0.3 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: P16627, P34931, P55063
• Gene Symbols: Hspa1l
• Immunogen: Recombinant protein corresponding to Human HSP701L
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Research Use Only