Thermo Scientific Chemicals G418 sulfate, for biochemistry

Description

G418 sulfate, geneticin, CAS # 108321-42-2, is an antibiotic closely related to Gentamicin B, the common aminoglycoside antibiotic.

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General description

• G418 sulfate (geneticin) is an aminoglycoside antibiotic isolated from Micromonospora rhodorangea
• G418 is a bacteriostatic that prevents polypeptide formation by inhibiting the elongation step of polypeptide synthesis

Applications

• G418 sulfate can be used for selection of genetically engineered cells in both eukaryotes and prokaryotes
• Laboratory grade for applications such as biochemistry

Specifications

Chemical Identifiers

• CAS: 108321-42-2
• Molecular Formula: C20H44N4O18S2
• Molecular Weight (g/mol): 692.70
• MDL Number: MFCD00058314
• InChI Key: UHEPSJJJMTWUCP-KETIWVBHNA-N
• PubChem CID: 134129582
• SMILES: OS(O)(=O)=O.OS(O)(=O)=O.CN[C@@H]1[C@@H](O)[C@@H](O[C@H]2[C@H](N)C[C@H](N)[C@@H](O[C@H]3O[C@H](C(C)O)[C@@H](O)[C@H](O)[C@H]3N)[C@@H]2O)OC[C@]1(C)O

• Type: G418 Sulfate
• Physical Form: Powder
• Infrared Spectrum: Authentic
• Packaging: Glass Bottle
• Solubility Information: Solubility in water: soluble.
• IUPAC Name: (2R,3R,4R,5R)-2-[(1S,2R,3R,4S,6R)-4,6-diamino-3-[(2S,3S,4R,5S,6R)-3-amino-4,5-dihydroxy-6-[(1R)-1-hydroxyethyl]oxan-2-yl]oxy-2-hydroxycyclohexyl]oxy-5-methyl-4-(methylamino)oxane-3,5-diol;sulfuric acid
• Formula Weight: 692.7
• Grade: Biochemical
• Water: 10% max.
• Color: White
• Quantity: 5 g
• Chemical Name or Material: G418 sulfate

Safety and Handling

Product Identifier

• G418 sulfate

Signal Word

• Danger

Hazard Category

• Reproductive toxicity Category 1A
• Respiratory sensitiser Category 1
• Skin sensitiser Category 1

Hazard Statement

• H317-May cause an allergic skin reaction.
• H360FD-May damage fertility. May damage the unborn child.
• H334-May cause allergy or asthma symptoms or breathing difficulties if inhaled.

Precautionary Statement

• P201-Obtain special instructions before use.
• P261-Avoid breathing dust/fume/gas/mist/vapours/spray.
• P280-Wear protective gloves/protective clothing/eye protection/face protection.
• P308+P313-IF exposed or concerned: Get medical advice/attention.
• P342+P311-If experiencing respiratory symptoms: Call a POISON CENTER/doctor/ .

RUO – Research Use Only