Epredia™ Lab Vision™ Estrogen Receptor Ab-12, Mouse Monoclonal Antibody

Ensure accurate, reproducible results in immunohistochemistry, western blotting and immunoprecipitation experiments.

Brand:  Epredia™ MS-391-S1

Product Code. 12611297

Description

The ER gene consists of more than 140kb of genomic DNA divided into 8 exons and is translated into a protein with six functionally discrete domains required for transcription activation function, binding to estrogen response element (ERE) constitutive dimerization, binding to heat shock proteins, and ligand recognition. The ER is an important regulator of growth and differentiation in the mammary gland. Presence of ER in breast tumors indicates an increased likelihood of response to anti-estrogen (e.g. tamoxifen) therapy.

Host Species: Mouse

Clone: 6F11

Isotype: IgG1

Species Reactivity: Human and Rat. Others not known.

Immunogen: Recombinant full-length estrogen receptor protein

Molecular Weight: 67 kDa

Positive Control: MCF-7 cells, Breast CA

Cellular Localization: Nuclear

Recommended for:

• Immunohistochemistry (Formalin/paraffin)
• Western Blotting
• Immunoprecipitation (Denatured verified)

Note:

USA: RUO; Int'l: RUO

Specifications

• Antigen: Estrogen Receptor Ab-12
• Classification: Monoclonal
• Conjugate: Unconjugated
• Immunogen: Recombinant full length estrogen receptor protein
• Quantity: 500 μL
• Research Discipline: Steroids Hormones and Growth Factors
• Target Species: Human, Rat
• Isotype: IgG1

• Applications: Immunoprecipitation
• Clone: 6F11
• Host Species: Mouse
• Purification Method: MCF-7 cells, breast CA
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Form: Concentrated