Estrogen Receptor Ab-11 Mouse Monoclonal Antibody, Epredia™

Obtain accurate, reproducible results in immunohistochemistry and western blotting experiments with Epredia™ Estrogen Receptor Ab-11, Mouse Monoclonal Antibody.

Brand:  Epredia MS-354-P

Product Code. 12631137

Description

The ER gene consists of more than 140kb of genomic DNA divided into 8 exons and is translated into a protein with six functionally discrete domains required for transcription activation function, binding to estrogen response element (ERE) constitutive dimerization, binding to heat shock proteins, and ligand recognition. The ER is an important regulator of growth and differentiation in the mammary gland. Presence of ER in breast tumors indicates an increased likelihood of response to anti-estrogen (e.g. tamoxifen) therapy.

Host Species: Mouse

Clone: 1D5

Isotype: IgG1/κ

Species Reactivity: Human, Monkey, Mouse and Rat. Others not known.

Epitope: N-terminal domain

Immunogen: Recombinant human estrogen receptor protein

Molecular Weight: 67 kDa

Positive Control: MCF-7 cells, Breast CA

Cellular Localization: Nuclear

Recommended for:

• Immunohistochemistry (Formalin/paraffin)
• Western Blotting

Specifications

• Antigen: Estrogen Receptor Ab-11
• Classification: Monoclonal
• Concentration: 200μg/mL
• Host Species: Mouse
• Quantity: 1 mL
• Research Discipline: Steroids Hormones and Growth Factors
• Target Species: Human, Mouse, Non-human Primate, Rat
• Isotype: IgG2a κ

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Clone: 1D5
• Conjugate: Unconjugated
• Immunogen: Recombinant human estrogen receptor protein
• Regulatory Status: ASR, IVD
• Primary or Secondary: Primary
• Form: Concentrated