Epstein Barr Virus Bcl-2 Monoclonal Antibody (D44E), Invitrogen™

Mouse Monoclonal Antibody

Brand:  Invitrogen MA17275

Product Code. 11530422

Description

The MA1-7275 antibody reacts with Epstein-Barr virus Bcl-2 in viral and infected tissue samples. MA1-7275 has been successfully used in ELISA, Western blot, Immunohistochemical and Immunoprecipitation applications. The MA1-7275 antibody was raised against EBV BCl-2 homolog protein.

Epstein-Barr virus (EBV) is a human herpes virus, which is associated with conditions such as Hodgkin's disease and Burkitt's Lymphoma and is the causative agent in mononucleosis in adolescents. EBV latently infects B lymphocytes. Infected B cells express EBV nuclear antigens and latent proteins LMP1, LMP2A and LMP2B. LMP2A forms aggregates in the plasma membranes of B lymphocytes, where it functions as a negative regulator of the Src and Syk protein tyrosine kinases. Studies show that LMP2A blocks B-cell receptor (BCR) signal transduction in EBV immortalized B cells in vitro and may play an important role in maintaining a latent EBV infection within the peripheral blood B cells of infected individuals.EBNA-1 is the only viral protein consistently expressed in all malignancies associated with EBV.

Specifications

• Antigen: Epstein Barr Virus Bcl-2
• Classification: Monoclonal
• Concentration: 0.1 mg/mL
• Formulation: PBS with 0.1% sodium azide; pH 7.2
• Host Species: Mouse
• Purification Method: Protein A
• Regulatory Status: RUO
• Target Species: Virus
• Product Type: Antibody
• Isotype: IgG1

• Applications: ELISA, Immunohistochemistry, Immunoprecipitation, Western Blot
• Clone: D44E
• Conjugate: Unconjugated
• Gene Alias: EBV; EBV bcl2; EBV Bcl-2
• Immunogen: EBV BCl-2 homolog.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Content And Storage: 4° C
• Form: Liquid