missing translation for 'onlineSavingsMsg'
Learn More

Bleomycin sulfate, Thermo Scientific Chemicals

Catalog Number 15483439
254.70 GBP valid until 2024-03-30
Use promo code "21648" to get your promotional price.


188.67 GBP valid until 2024-03-29
Use promo code "21615" to get your promotional price.


Click to view available options
Quantity:
10 mg
This item is not returnable. View return policy
To receive the discount customers must purchase three of the same product at list price in a single order to receive 33.33% discount. There is no limit to the multiples of 3 that customers can buy. Use promo code ”21615” to get your promotional price
9041-93-4
C55H85N17O25S4
1512.619
MFCD00070310
WUIABRMSWOKTOF-UHFFFAOYSA-N
131664136
[2-[2-[2-[[6-amino-2-[3-amino-1-[(2,3-diamino-3-oxopropyl)amino]-3-oxopropyl]-5-methylpyrimidine-4-carbonyl]amino]-3-[[5-[[1-[2-[4-[4-(3-dimethylsulfoniopropylcarbamoyl)-1,3-thiazol-2-yl]-1,3-thiazol-2-yl]ethylamino]-3-hydroxy-1-oxobutan-2-yl]amino]-3-hyd
CC1=C(N=C(N=C1N)C(CC(=O)N)NCC(C(=O)N)N)C(=O)NC(C(C2=CN=CN2)OC3C(C(C(C(O3)CO)O)O)OC4C(C(C(C(O4)CO)O)OC(=N)[O-])O)C(=O)NC(C)C(C(C)C(=O)NC(C(C)O)C(=O)NCCC5=NC(=CS5)C6=NC(=CS6)C(=O)NCCC[S+](C)C)O.OS(=O)(=O)O
This item is not returnable. View return policy
To receive the discount customers must purchase three of the same product at list price in a single order to receive 33.33% discount. There is no limit to the multiples of 3 that customers can buy. Use promo code ”21615” to get your promotional price
9041-93-4
C55H85N17O25S4
1512.619
MFCD00070310
WUIABRMSWOKTOF-UHFFFAOYSA-N
131664136
[2-[2-[2-[[6-amino-2-[3-amino-1-[(2,3-diamino-3-oxopropyl)amino]-3-oxopropyl]-5-methylpyrimidine-4-carbonyl]amino]-3-[[5-[[1-[2-[4-[4-(3-dimethylsulfoniopropylcarbamoyl)-1,3-thiazol-2-yl]-1,3-thiazol-2-yl]ethylamino]-3-hydroxy-1-oxobutan-2-yl]amino]-3-hyd
CC1=C(N=C(N=C1N)C(CC(=O)N)NCC(C(=O)N)N)C(=O)NC(C(C2=CN=CN2)OC3C(C(C(C(O3)CO)O)O)OC4C(C(C(C(O4)CO)O)OC(=N)[O-])O)C(=O)NC(C)C(C(C)C(=O)NC(C(C)O)C(=O)NCCC5=NC(=CS5)C6=NC(=CS6)C(=O)NCCC[S+](C)C)O.OS(=O)(=O)O

Bleomycin sulfate, CAS # 9041-93-4, is a glycopeptide compound with antibiotic activity isolated from Streptomyces verticillus. It also exhibits anticancer activity.

Bleomycin sulfate is used as a glycopeptide antibiotic. It is capable of inducing oxidative cleavage of the DNA backbone, leading to apoptosis and also degrades RNA, and has been reported to display selectivity for RNA over DNA. Bleomycin acts as a sclerosing agent.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

  • Bleomycin sulfate was initially isolated from Streptomyces verticillus. It is a glycopeptide compound with antibiotic activity
  • It has the ability to induce oxidative cleavage of the DNA backbone, leading to apoptosis
  • Bleomycin sulfate can form a complex with iron that reduces oxygen to superoxide and hydroxyl radicals. These reactive oxygen species can cause single- and double-stranded breaks in DNA as well as promote carbohydrate oxidation, lipid peroxidation, and alterations in prostaglandin synthesis and degradation

Application

  • It can be used to inhibit DNA metabolism and slow or stop cell growth. This property explains its anticancer activity
  • Bleomycin sulfate can also be used to degrade RNA as it is more selective to RNA than DNA
  • Local injections of bleomycin sulfate in mouse models can induce sclerotic skin mimicking scleroderma
  • In laboratory research, bleomycin is used to induce pulmonary fibrosis in mice
TRUSTED_SUSTAINABILITY
Type Bleomycin Sulfate
Physical Form Powder
Merck Index 14,1318
Solubility Information Soluble in water or DMSO
Color White
Quantity 10 mg
Chemical Name or Material Bleomycin sulfate

RUO – Research Use Only

missing translation for 'provideContentCorrection'

missing translation for 'productTitle'