BD Caspase-8

Play role in apoptosis induced by death receptors

Brand:  BD 556481

Product Code. 15808718

Description

Caspases are cysteine proteases that play central role in apoptosis. The caspase family was discovered by searching human cDNA libraries for sequences homologous to ced-3, a C. elegans death gene that is required for normal apoptosis during development

• Fas and tumor necrosis factor receptor type 1 (TNFR1)
• One of its substrates is poly (ADP ribose) polymerase (PARP)
• PARP is an enzyme that is involved in DNA repair and genomic maintenance
• Cleaves PARP from its 116kDa form to 85kDa residual fragment
• The cleavage site in PARP is C-terminal to Asp-216
• Utilized as basis for highly specific caspase-3 substrates such as Ac(N-acetyl)-DEVD-AFC (7-amino-4-trifluoromethylcourmarin) and Ac(N-acetyl)-DEVD-AMC (7-amino-4-methylcoumarin) as well as caspase-3 aldehyde inhibitor Ac-DEVD-CHO
• Format: Purified

Fluorescence quantitation

Specifications

• Concentration: 0.2mg/mL
• Name: Human Caspase-8 Protease Recombinant Protein
• Storage Requirements: -80°C
• Recombinant: Recombinant

• For Use With (Application): Fluorescence Quantitation
• Quantity: 5μg
• Cross Reactivity: Human

Research use only