BD Caspase-3, Active Form, mAb Apoptosis Kit

Specific recognision of active form of caspase-3 in human and mouse cells

Brand:  BD 550914

Product Code. 15876428

Includes: PE-conjugated Monoclonal Rabbit Anti-Active Caspase-3 Antibody, BD Cytofix/Cytoperm™ Fixation/Permeabilization Solution, and BD Perm/Wash™ Buffer

Description

Cysteine proteases plays key role in apoptosis and inflammation. Caspase-3 being key protease is activated during early stages of apoptosis and, like other members of caspase family, is synthesized as inactive pro-enzyme that is processed in cells undergoing apoptosis by self-proteolysis and/or cleavage by another protease. The processed forms of caspases consist of large (17-22 kDa) and small (10-12 kDa) subunits which associate to form active enzyme. Active caspase-3, a marker for cells undergoing apoptosis, consists of heterodimer of 17 and 12 kDa subunits which is derived from the 32 kDa pro-enzyme. Active caspase-3 proteolytically cleaves and activates other caspases, as well as relevant targets in cytoplasm and nucleus. This antibody has been reported to specifically recognize the active form of caspase-3 in human and mouse cells.

• Clone: C92-605
• Format: PE
• Isotype: IgG

Intracellular staining (flow cytometry)

Specifications

• Quantity: 1 Kit
• Content And Storage: 4°C
• For Use With (Application): Intracellular Staining
• Form: Liquid

Research use only