anti-MDM2 Clone: 4H26L4, Invitrogen™
MDM2 Monoclonal antibody 700555 from Thermo Scientific™ Pierce™ specifically detects MDM2 in Human samples, and it is validated for WB
Brand: Invitrogen 700555
Code : NEW
Additional Details : Weight : 0.01000kg
MDM2 also known as murine double minute 2, is found to interact with p53; a tumor suppressor protein, and has been shown to negatively regulate its function. MDM2 binds and inhibits transactivation role played by p53 and overexpression of MDM2 can result in the inactivation of p53 and in turn decrease its tumor suppressor function. Another process by which MDM2 can inactivate p53 is by degrading p53 as the protein also possesses E3 ubiquitin ligase activity. MDM2 also plays various important roles in apoptosis and cell cycle. MDM2 is located on chromosome 12 on the q arm.
700555 detects MDM2 in Human samples. 700555 has been successfully used in WB procedures. The immunogen for 700555 is recombinant protein corresponding to amino acids 215-422 of human MDM2.
|Store at 2 to 8°C for up to 1 month. For long term storage, store at -20°C.|
|100μg of Protein A antibody in PBS with 0.09% sodium azide;|
|Recombinant protein corresponding to amino acids 215-422 of human MDM2.|