HYAL2 Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Brand:  Invitrogen PA524223

Product Code. 13212099

Description

This gene encodes a weak acid-active hyaluronidase. The encoded protein is similar in structure to other more active hyaluronidases. Hyaluronidases degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan and fragments of hyaluronan are thought to be involved in cell proliferation, migration and differentiation. Although it was previously thought to be a lysosomal hyaluronidase that is active at a pH below 4, the encoded protein is likely a GPI-anchored cell surface protein. This hyaluronidase serves as a receptor for the oncogenic virus Jaagsiekte sheep retrovirus. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. This gene encodes two alternatively spliced transcript variants which differ only in the 5' UTR.

Specifications

• Antigen: HYAL2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: HYAL2
• Gene Alias: AI256841; AU020858; AW555733; HYAL2; Hyal-2; Hyaluronidase; hyaluronidase 2; hyaluronidase-2; hyaluronoglucosaminidase 2; hyaluronoglucosaminidase-2; LUCA2; LuCa-2; lung carcinoma protein 2; lysosomal hyaluronidase; PH20 homolog; PH-20 homolog
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography, Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 8692
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.25 mg/mL
• Formulation: PBS with 0.09% sodium azide
• Gene Accession No.: Q12891
• Gene Symbols: HYAL2
• Immunogen: KLH conjugated synthetic peptide between 385-412 amino acids from the C-terminal region of human HYAL2
• Quantity: 400 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG