A23187, 98%, free acid, Thermo Scientific Chemicals

Product Code	Brand	Quantity	Packaging
10397811	Thermo Scientific Acros 328080010	1 mg	Glass Bottle in Plastic Container
10036163	Thermo Scientific Acros 328080050	5 mg	Glass Bottle

Description

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General description

• A23187 is a polyether substance that permeabilizes cell membranes to calcium and other divalent cations

Applications
• A23187 can be used for the study of mitochondrial physiology because it acts as an uncoupling agent
• A23187 can be used to study the roles of divalent cations in cell physiology
• When bound to fluorescent calcium ions, A23187 can be useful for imaging studies

Chemical Identifiers

• CAS: 52665-69-7
• Molecular Weight (g/mol): 523.63
• InChI Key: HIYAVKIYRIFSCZ-CVXKHCKVSA-N
• IUPAC Name: 5-(methylamino)-2-[[(2R,3S,5S,6S,8S,9S)-3,5,9-trimethyl-2-[(2S)-1-oxo-1-(1H-pyrrol-2-yl)propan-2-yl]-1,7-dioxaspiro[5.5]undecan-8-yl]methyl]-1,3-benzoxazole-4-carboxylic acid

• Molecular Formula: C29H37N3O6
• MDL Number: MFCD00151202,MFCD00151202
• PubChem CID: 97043288
• SMILES: CNC1=CC=C2OC(C[C@@H]3OC4(CC[C@@H]3C)O[C@H](C(C)C(=O)C3=CC=CN3)[C@H](C)C[C@H]4C)=NC2=C1C(O)=O

Specifications

• Physical Form: Solid
• CAS Min %: 97.5
• Melting Point: 182.0°C to 193.0°C
• Assay Percent Range: 98%
• MDL Number: MFCD00151202,MFCD00151202
• Solubility Information: Solubility in water: .. Other solubilities: soluble in dmso, ethylacetate, methanol, ethanol
• SMILES: CNC1=CC=C2OC(C[C@@H]3OC4(CC[C@@H]3C)O[C@H](C(C)C(=O)C3=CC=CN3)[C@H](C)C[C@H]4C)=NC2=C1C(O)=O
• Molecular Weight (g/mol): 523.63
• Formula Weight: 523.63
• Color: White

• CAS: 52665-69-7
• CAS Max %: 100.0
• Infrared Spectrum: Authentic
• Molecular Formula: C29H37N3O6
• Merck Index: 15, 1642
• InChI Key: HIYAVKIYRIFSCZ-CVXKHCKVSA-N
• IUPAC Name: 5-(methylamino)-2-[[(2R,3S,5S,6S,8S,9S)-3,5,9-trimethyl-2-[(2S)-1-oxo-1-(1H-pyrrol-2-yl)propan-2-yl]-1,7-dioxaspiro[5.5]undecan-8-yl]methyl]-1,3-benzoxazole-4-carboxylic acid
• PubChem CID: 97043288
• Percent Purity: 98%
• Chemical Name or Material: A23187, Free acid

Safety and Handling

GHS H Statement:
Harmful in contact with skin.
Harmful if inhaled.
May cause respiratory irritation.
Causes skin irritation.
Harmful if swallowed.
Causes serious eye irritation.

GHS P Statement:
IF ON SKIN: Wash with plenty of soap and water.
Wear protective gloves/protective clothing/eye protection/face protection.
Avoid breathing dust/fume/gas/mist/vapors/spray.
IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
Wear protective gloves/protective clothing/eye protection/face protection.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

WARNING: The information provided on this web site was developed in compliance with European Union (EU) regulations and is correct to the best of our knowledge, information and belief at the date of its publication. The information given is designed only as a guide for safe handling and use. It is not to be considered as either a warranty or quality specification.

GHS Signal Word: Warning

Product Identifier

• A23187 (free acid)

Signal Word

• Warning

Hazard Category

• Acute toxicity Category 4
• Serious eye damage/eye irritation Category 2
• Skin corrosion/irritation Category 2
• Specific target organ toxicity Category 3

Hazard Statement

• H315-Causes skin irritation.
• H319-Causes serious eye irritation.
• H335-May cause respiratory irritation.
• H312-Harmful in contact with skin.
• H332-Harmful if inhaled.
• H302-Harmful if swallowed.

Precautionary Statement

• P261-Avoid breathing dust/fume/gas/mist/vapours/spray.
• P280-Wear protective gloves/protective clothing/eye protection/face protection.
• P301+P312-IF SWALLOWED: Call a POISON CENTER or doctor/physician/ if you feel unwell.
• P302+P352-IF ON SKIN: Wash with plenty of water/.
• P304+P340-IF INHALED: Remove person to fresh air and keep comfortable for breathing.
• P305+P351+P338-IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

RUO – Research Use Only