4,5-Dimethoxy-2-nitrobenzyl chloroformate, 97%, Thermo Scientific Chemicals

Product Code	Brand	Quantity
15478999	Thermo Scientific Alfa Aesar L14167.MD	250 mg
15468999	Thermo Scientific Alfa Aesar L14167.03	1 g

Description

4,5-Dimethoxy-2-nitrobenzyl chloroformate is used as a reagent for protection of amines, for use in N-protection of bases in nucleotide synthesis, photochemical protecting groups in organic synthesis. It is used as pharmaceutical intermediate.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
4,5-Dimethoxy-2-nitrobenzyl chloroformate is used as a reagent for protection of amines, for use in N-protection of bases in nucleotide synthesis, photochemical protecting groups in organic synthesis. It is used as pharmaceutical intermediate.

Solubility
Soluble in methanol, acetone. Reacts with water.

Notes
Moisture and light sensitive. Store away from oxidizing agents, light, water/ moisture, heat, bases.

Chemical Identifiers

• CAS: 42855-00-5
• Molecular Weight (g/mol): 275.641
• InChI Key: RWWPKIOWBQFXEE-UHFFFAOYSA-N
• PubChem CID: 3084878
• SMILES: COC1=C(C=C(C(=C1)COC(=O)Cl)[N+](=O)[O-])OC

• Molecular Formula: C10H10ClNO6
• MDL Number: MFCD00143507
• Synonym: 4,5-dimethoxy-2-nitrobenzyl carbonochloridate, nvoc-cl, 4,5-dimethoxy-2-nitrobenzyl chloroformate, 6-nitroveratryl chloroformate, nitroveratryl oxy chlorocarbamate, 6-nitroveratryloxycarbonyl chloride, carbonochloridic acid, 4,5-dimethoxy-2-nitrophenyl methyl ester, 4,5-dimethoxy-2-nitrophenyl methyl chloroformate, 4,5-dimethoxy-2-nitrophenyl methyl carbonochloridate, nvoc chloride
• IUPAC Name: (4,5-dimethoxy-2-nitrophenyl)methyl carbonochloridate

Specifications

• CAS: 42855-00-5
• Molecular Formula: C10H10ClNO6
• UN Number: UN3261
• Synonym: 4,5-dimethoxy-2-nitrobenzyl carbonochloridate, nvoc-cl, 4,5-dimethoxy-2-nitrobenzyl chloroformate, 6-nitroveratryl chloroformate, nitroveratryl oxy chlorocarbamate, 6-nitroveratryloxycarbonyl chloride, carbonochloridic acid, 4,5-dimethoxy-2-nitrophenyl methyl ester, 4,5-dimethoxy-2-nitrophenyl methyl chloroformate, 4,5-dimethoxy-2-nitrophenyl methyl carbonochloridate, nvoc chloride
• SMILES: COC1=C(C=C(C(=C1)COC(=O)Cl)[N+](=O)[O-])OC
• Molecular Weight (g/mol): 275.641
• Formula Weight: 275.64
• Chemical Name or Material: 4,5-Dimethoxy-2-nitrobenzyl chloroformate

• Melting Point: ∼120°C
• MDL Number: MFCD00143507
• Beilstein: 2389168
• InChI Key: RWWPKIOWBQFXEE-UHFFFAOYSA-N
• IUPAC Name: (4,5-dimethoxy-2-nitrophenyl)methyl carbonochloridate
• PubChem CID: 3084878
• Percent Purity: 97%

Safety and Handling

GHS H Statement
H314-H318
Causes severe skin burns and eye damage.
Causes serious eye damage.

GHS P Statement
P260-P303+P361+P353-P305+P351+P338-P301+P330+P331-P405-P501a
Do not breathe dust/fume/gas/mist/vapors/spray.
IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
Store locked up.
Dispose of contents/container in accordance with local/regional/national/international regulations.

Danger

missing translation for 'dotInformation' : Transport Hazard Class: 8; Packing Group: II; Proper Shipping Name: CORROSIVE SOLID, ACIDIC, ORGANIC, N.O.S.

Recommended Storage : 2° to 8°C

RUO – Research Use Only