2,2-Difluoroacetophenone, 95%, Thermo Scientific Chemicals

Description

2,2-Difluoroacetophenone acts as an intermediate in the preparation of various substances such as pharmaceuticals. Further, it is used in the one-pot synthesis of difluoromethylated arenes from aryl chlorides and bromides. In addition to this, it undergoes reduction with (-)-diisopinocampheylchloroborane chloride to get R-alcohols of purity 85% ee.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
2,2-Difluoroacetophenone acts as an intermediate in the preparation of various substances such as pharmaceuticals. Further, it is used in the one-pot synthesis of difluoromethylated arenes from aryl chlorides and bromides. In addition to this, it undergoes reduction with (-)-diisopinocampheylchloroborane chloride to get R-alcohols of purity 85% ee.

Solubility
Immiscible with water.

Notes
Incompatible with strong oxidizing agents and strong acids.

Specifications

Chemical Identifiers

• CAS: 395-01-7
• Molecular Formula: C8H6F2O
• Molecular Weight (g/mol): 156.132
• MDL Number: MFCD06246879
• InChI Key: OLYKCPDTXVZOQF-UHFFFAOYSA-N
• Synonym: 2,2-difluoroacetophenone, alpha,alpha-difluoroacetophenone, 2,2-difluoro-1-phenyl-ethanone, 2,2-difluoro-1-phenylethan-1-one, a,a-difluoroacetophenone, ethanone, 2,2-difluoro-1-phenyl, difluoromethyl phenyl ketone, difluoroacetophenone, acmc-20aojw, acetophenone, 2,2-difluoro
• PubChem CID: 273286
• IUPAC Name: 2,2-difluoro-1-phenylethanone
• SMILES: C1=CC=C(C=C1)C(=O)C(F)F

• Melting Point: 48°C to 50°C
• Boiling Point: 53°C to 54°C (12 mmHg)
• Odor: Characteristic
• Refractive Index: 1.4955
• Quantity: 250 mg
• Solubility Information: Immiscible with water.
• Formula Weight: 156.13
• Percent Purity: 95%
• Chemical Name or Material: 2,2-Difluoroacetophenone

RUO – Research Use Only