QIAGEN QIAcard FTA DMPK

For collection, stabilization, processing, transport and archiving of biological samples. 4 sample areas per card.

Brand:  QIAGEN WB129242

Product Code. 15346165

Description

For collection, stabilization, processing, transport and archiving of biological samples. 4 sample areas per card.

QIAcard FTA DMPK Cards for Drug Metabolism Pharmacokinetic enable microvolume sampling with only 10 to 20 μL per sample and are designed for use with blood samples. The cards can also be used with colorless samples such as plasma, cerebrospinal fluid and urine.

QIAcard FTA DMPK-A and QIAcard FTA DMPK-B contains impregnated chemicals enabling protein denaturation to inactivate endogenous enzymes. Cell lysis releases endogenous cellular materials onto card. Stabilization of DNA allows resampling of blood spot for pharmacogenomics.Impregnated chemicals may interfere with mass spectrometry detection (e.g. ion suppression).

QIAcard FTA DMPK-C contain pure cellulose. No impregnated chemicals to interfere with analysis. Proteins are not denatured so cards may be better suited for protein based biomolecules and antibody studies.

Analysis:

Analysis primarily with HPLC or UHPLC followed by MS/MS detection, direct desorption MS techniques such as DESI. Methanol or aqueous/organic mixtures have been shown to work well for small molecules and aqueous buffers are recommended for proteins.

Select a good solvent for the analyte while maintaining compatibility with the HPLC conditions to be used. The choice of DMPK card depends on many factors such as the analyte chemical structure, extraction solvent and analysis workflow.

Specifications

• Format: Card
• For Use With (Application): For protein-based biomolecules, on-substrate cleanup has potential to convey greater analyte stability, requires fewer experimental animals
• Key Functions: Contains impregnated chemicals enabling protein denaturation to inactivate endogenous enzymes. Cell lysis releases endogenous cellular materials onto card. Stabilization of DNA allows resampling of blood spot for pharmacogenomics.

• Formulation: Type B
• Includes: 100 cards
• Product Type: QIAcard FTA DMPK-B

Safety and Handling

Signal Word

• Warning

Hazard Category

• Acute toxicity Category 4
• LONG-TERM AQUATIC HAZARD Chronic 3

Hazard Statement

• H302 + H312 + H332-Harmful if swallowed, in contact with skin or if inhaled.
• H412-Harmful to aquatic life with long lasting effects.

Precautionary Statement

• P280-Wear protective gloves/protective clothing/eye protection/face protection.
• P273-Avoid release to the environment.
• P304+P340-IF INHALED: Remove person to fresh air and keep comfortable for breathing.
• P312-Call a POISON CENTER/doctor/if you feel unwell.
• P501-Dispose of contents/container to .