Trimethylsilyl cyanide, 97%, Thermo Scientific Chemicals

Product Code	Brand	Quantity
11494147	Thermo Scientific Alfa Aesar A19598.06	5 g
11404157	Thermo Scientific Alfa Aesar A19598.14	25 g
11414157	Thermo Scientific Alfa Aesar A19598.22	100 g

Description

Trimethylsilyl Cyanide is used as a reagent in the preparation of optically active cyanohydrins. It is used in the derivatization of complex metabolite mixtures by GC-MS. It is employed in the preparation of Reissert compounds, which represent reactive polyamides. Further, it is used to convert pyridine-N-oxides into 2-cyanopyridine. It is also used as a cyanide source in an enantioselective organocatalytic Strecker-type reaction of aliphatic N,N-dialkylhydrazones. In addition to this, it is used as a reagent for the cyanosilylation of aldehydes.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Trimethylsilyl Cyanide is used as a reagent in the preparation of optically active cyanohydrins. It is used in the derivatization of complex metabolite mixtures by GC-MS. It is employed in the preparation of Reissert compounds, which represent reactive polyamides. Further, it is used to convert pyridine-N-oxides into 2-cyanopyridine. It is also used as a cyanide source in an enantioselective organocatalytic Strecker-type reaction of aliphatic N,N-dialkylhydrazones. In addition to this, it is used as a reagent for the cyanosilylation of aldehydes.

Solubility
Miscible with organic solvents.

Notes
Moisture sensitive. Store in a cool place.Incompatible with water, strong oxidizing agents, strong reducing agents, strong acids and strong bases.

Chemical Identifiers

• CAS: 7677-24-9
• Molecular Weight (g/mol): 99.21
• InChI Key: LEIMLDGFXIOXMT-UHFFFAOYSA-N
• PubChem CID: 82115
• SMILES: C[Si](C)(C)C#N

• Molecular Formula: C4H9NSi
• MDL Number: MFCD00001765
• Synonym: trimethylsilyl cyanide, cyanotrimethylsilane, trimethylsilanecarbonitrile, trimethylsilylcyanide, silanecarbonitrile, trimethyl, trimethylsilylnitrile, tmscn, trimethyl silane cyanide, trimethylsilylcarbonitrile, tms cyanide
• IUPAC Name: trimethylsilylformonitrile

Specifications

• Boiling Point: 118°C to 119°C
• CAS: 7677-24-9
• MDL Number: MFCD00001765
• Beilstein: 1737612
• Synonym: trimethylsilyl cyanide, cyanotrimethylsilane, trimethylsilanecarbonitrile, trimethylsilylcyanide, silanecarbonitrile, trimethyl, trimethylsilylnitrile, tmscn, trimethyl silane cyanide, trimethylsilylcarbonitrile, tms cyanide
• InChI Key: LEIMLDGFXIOXMT-UHFFFAOYSA-N
• IUPAC Name: trimethylsilylformonitrile
• PubChem CID: 82115
• Percent Purity: 97%
• Refractive Index: 1.391
• Density: 0.783

• Melting Point: 11°C to 12°C
• Molecular Formula: C4H9NSi
• UN Number: UN3383
• Flash Point: 1°C (33°F)
• Solubility Information: Miscible with organic solvents.
• SMILES: C[Si](C)(C)C#N
• Molecular Weight (g/mol): 99.21
• Formula Weight: 99.21
• Odor: Almond-like
• Sensitivity: Moisture sensitive
• Chemical Name or Material: Trimethylsilyl cyanide

Safety and Handling

GHS H Statement
H225-H300-H310-H330
Highly flammable liquid and vapour.
Fatal if swallowed.
Fatal in contact with skin.
Fatal if inhaled.

P210-P233-P235-P240-P241-P242-P243-P260-P262-P264b-P270-P271-P280-P284-P301+P310-P303+P361+P353-P304+P340-P310-P330-P363-P370+P378q-P501c

H225-H300+H310+H330

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Recommended Storage : Ambient temperatures

Product Identifier

• Trimethylsilyl cyanide

Signal Word

• Danger

Hazard Category

• Acute toxicity Category 1
• LONG-TERM AQUATIC HAZARD Chronic 1
• Flammable liquid Category 2

Hazard Statement

• H225-Highly flammable liquid and vapour.
• H300-Fatal if swallowed.
• H310-Fatal in contact with skin.
• H330-Fatal if inhaled.
• H410-Very toxic to aquatic life with long lasting effects.
• EUH029-Contact with water liberates toxic gas.

Precautionary Statement

• P210-Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.
• P264-Wash face, hands and anyexposed skin thoroughly after handling.
• P280-Wear protective gloves/protective clothing/eye protection/face protection.
• P301+P330+P331-IF SWALLOWED: rinse mouth. Do NOT induce vomiting.
• P303+P361+P353-IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water/ shower.
• P310-Immediately call a POISON CENTER/doctor/.

Supplemental information

• MIXTURE LIST-Contains : Trimethylsilyl cyanide

RUO – Research Use Only