RAB5A Rabbit anti-Human, Mouse, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Product Code	Brand	Quantity
16879744	Proteintech 20228-1-AP-20UL	20 μL
16869744	Proteintech 20228-1-AP-150UL	150 μL

Description

The antibody is specific to RAB5A. It has no cross reaction to RAB5B or RAB5C.

RAB5 are among the small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes. Contributes to the regulation of filopodia extension. Required for the exosomal release of SDCBP, CD63, PDCD6IP and syndecan. Regulates maturation of apoptotic cell-containing phagosomes, probably downstream of DYN2 and PIK3C3.

Specifications

• Antigen: RAB5A
• Applications: Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot, Immunoprecipitation, Immunocytochemistry
• Conjugate: Unconjugated
• Host Species: Rabbit
• Target Species: Mouse, Human
• Gene Accession No.: P20339, Q9CQD1
• Gene ID (Entrez): 271457, 5868
• Immunogen: Peptide
• Primary or Secondary: Primary
• Content And Storage: -20°C
• Gene: RAB5A

• Concentration: 0.22 mg/mL
• Classification: Polyclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Alias: RAB5, RAB5A, Ras related protein Rab 5A
• Gene Symbols: Rab5a
• Isotype: IgG
• Purification Method: Antigen Affinity Chromatography
• Product Type: Antibody